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- W2069835983 abstract "Despite dramatic fluctuations in calorie intake, animals maintain a very stable body weight. The reason is that energy intake and expenditure are precisely matched. Long-term regulation of energy balance is dependent on the coordination and interpretation of signals such as those given by insulin and leptin indicating sufficient long-term energy stores as well as short-term, meal-related signals such as those given by cholecystokinin (CCK). Within the last 30 years, our knowledge of short-term signals has increased dramatically. Throughout the cephalo-caudal axis of the gastrointestinal system, discrete enteroendocrine cells respond to both mechanical and chemical stimulation. Meal-associated hormone release is dependent on the concentration and composition of the nutrients ingested. Released signals are transmitted neurally through vagal afferents or humorally as circulating ligands for specific receptor populations in the periphery and central nervous system. These signals are interpreted by the CNS and manifested as a behavioral modification of feeding. This review will present past and recent literature in support of gut hormones and their roles as mediators of satiety. Evidence from pharmacologic and physiologic studies involving both humans and rodents will be presented, along with a short section outlining the knowledge gained through the use of murine knockout models. Last, the contribution of satiety hormones as likely mediators of the effectiveness seen following obesity surgery will be reviewed. Although traditionally thought of as short-term, meal-related signals, enhanced, chronic hormone secretion and signaling resulting from gut reconstruction as seen with gastric bypass surgery most likely contributes to the superior efficacy of surgery as a treatment for obesity." @default.
- W2069835983 created "2016-06-24" @default.
- W2069835983 creator A5064532254 @default.
- W2069835983 creator A5072321501 @default.
- W2069835983 date "2005-01-01" @default.
- W2069835983 modified "2023-10-11" @default.
- W2069835983 title "Gastrointestinal hormones and food intake" @default.
- W2069835983 cites W1483363426 @default.
- W2069835983 cites W148995908 @default.
- W2069835983 cites W1491025945 @default.
- W2069835983 cites W1502152603 @default.
- W2069835983 cites W1507814807 @default.
- W2069835983 cites W1508456959 @default.
- W2069835983 cites W1561443084 @default.
- W2069835983 cites W1575605880 @default.
- W2069835983 cites W1577188597 @default.
- W2069835983 cites W1590886519 @default.
- W2069835983 cites W1637971961 @default.
- W2069835983 cites W1650793501 @default.
- W2069835983 cites W1731897847 @default.
- W2069835983 cites W1852436006 @default.
- W2069835983 cites W1854143160 @default.
- W2069835983 cites W1909310469 @default.
- W2069835983 cites W1910418518 @default.
- W2069835983 cites W1936375955 @default.
- W2069835983 cites W1955101208 @default.
- W2069835983 cites W1957048593 @default.
- W2069835983 cites W1964984845 @default.
- W2069835983 cites W1965690960 @default.
- W2069835983 cites W1970160828 @default.
- W2069835983 cites W1972535859 @default.
- W2069835983 cites W1974094437 @default.
- W2069835983 cites W1974538948 @default.
- W2069835983 cites W1976083063 @default.
- W2069835983 cites W1976110253 @default.
- W2069835983 cites W1976921692 @default.
- W2069835983 cites W1979100850 @default.
- W2069835983 cites W1980130009 @default.
- W2069835983 cites W1982567180 @default.
- W2069835983 cites W1984981788 @default.
- W2069835983 cites W1984992349 @default.
- W2069835983 cites W1985051436 @default.
- W2069835983 cites W1985132004 @default.
- W2069835983 cites W1985210505 @default.
- W2069835983 cites W1985621101 @default.
- W2069835983 cites W1986298555 @default.
- W2069835983 cites W1988646125 @default.
- W2069835983 cites W1990651463 @default.
- W2069835983 cites W1991670388 @default.
- W2069835983 cites W1991714764 @default.
- W2069835983 cites W1993260804 @default.
- W2069835983 cites W1993941573 @default.
- W2069835983 cites W1994091958 @default.
- W2069835983 cites W1994722112 @default.
- W2069835983 cites W1995273292 @default.
- W2069835983 cites W1996634799 @default.
- W2069835983 cites W1996713062 @default.
- W2069835983 cites W1998200369 @default.
- W2069835983 cites W1998862696 @default.
- W2069835983 cites W1999413356 @default.
- W2069835983 cites W2000682521 @default.
- W2069835983 cites W2002134707 @default.
- W2069835983 cites W2005334239 @default.
- W2069835983 cites W2005359371 @default.
- W2069835983 cites W2007879964 @default.
- W2069835983 cites W2008480577 @default.
- W2069835983 cites W2008582388 @default.
- W2069835983 cites W2010328324 @default.
- W2069835983 cites W2010340764 @default.
- W2069835983 cites W2011989007 @default.
- W2069835983 cites W2012407394 @default.
- W2069835983 cites W2012721700 @default.
- W2069835983 cites W2013002120 @default.
- W2069835983 cites W2013058701 @default.
- W2069835983 cites W2013082477 @default.
- W2069835983 cites W2013583119 @default.
- W2069835983 cites W2014868997 @default.
- W2069835983 cites W2015503185 @default.
- W2069835983 cites W2017086778 @default.
- W2069835983 cites W2017105702 @default.
- W2069835983 cites W2018800952 @default.
- W2069835983 cites W2018895555 @default.
- W2069835983 cites W2019336862 @default.
- W2069835983 cites W2019385319 @default.
- W2069835983 cites W2020504228 @default.
- W2069835983 cites W2021162027 @default.
- W2069835983 cites W2021367638 @default.
- W2069835983 cites W2024146542 @default.
- W2069835983 cites W2024471505 @default.
- W2069835983 cites W2026244767 @default.
- W2069835983 cites W2027241056 @default.
- W2069835983 cites W2028388432 @default.
- W2069835983 cites W2028654736 @default.
- W2069835983 cites W2030307471 @default.
- W2069835983 cites W2031108469 @default.
- W2069835983 cites W2032450148 @default.
- W2069835983 cites W2032606140 @default.
- W2069835983 cites W2033937869 @default.