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• W2069837771 abstract "The syntheses and SAR of new series of β-amyloid binding agents are reported. The effort to optimize signal-to-background ratios for these ligands are described. Compounds 8, 21 and 30 displayed desirable lipophilicity and pharmacokinetic properties. Compounds 8 and 21 were evaluated with in vitro autoradiographic studies and in vivo in APP/PS1 transgenic mice. It is shown that it was possible to increase the signal-to-background ratios compared to PIB 1, as demonstrated by compounds 8 and 21." @default.
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• W2069837771 date "2010-03-01" @default.
• W2069837771 modified "2023-09-24" @default.
• W2069837771 title "Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for β-amyloid plaques" @default.
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• W2069837771 doi "https://doi.org/10.1016/j.bmcl.2010.01.105" @default.
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