Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069841283> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2069841283 endingPage "1643" @default.
- W2069841283 startingPage "1639" @default.
- W2069841283 abstract "N-Acetyltransferase 2 (NAT2) is one of the most important polymorphic drug-metabolizing enzymes and plays a significant role in individual differences of drug efficacies and/or side effects. Coenzyme A (CoA) is a cofactor in the experimentally determined crystal structure of NAT2, although the acetyl source of acetylation reactions catalyzed by NAT is not CoA, but rather acetyl CoA. In this study, the three-dimensional structure of NAT2, including acetyl CoA, was calculated using molecular dynamics simulation. By substituting acetyl CoA for CoA the amino acid residue Gly286, which is known to transform into a glutamate residue by NAT2*7A and NAT2*7B, comes close to the cofactor binding site. In addition, the binding pocket around the sulfur atom of acetyl CoA expanded in the NAT2–acetyl CoA complex." @default.
- W2069841283 created "2016-06-24" @default.
- W2069841283 creator A5028837265 @default.
- W2069841283 creator A5065081352 @default.
- W2069841283 creator A5077581823 @default.
- W2069841283 date "2010-01-01" @default.
- W2069841283 modified "2023-10-14" @default.
- W2069841283 title "Computational Study of the Three-Dimensional Structure of N-Acetyltransferase 2-Acetyl Coenzyme A Complex" @default.
- W2069841283 cites W1491175805 @default.
- W2069841283 cites W1528082070 @default.
- W2069841283 cites W1574489123 @default.
- W2069841283 cites W1581151107 @default.
- W2069841283 cites W1600133349 @default.
- W2069841283 cites W1973191530 @default.
- W2069841283 cites W1977570377 @default.
- W2069841283 cites W1996217549 @default.
- W2069841283 cites W2004373161 @default.
- W2069841283 cites W2030841140 @default.
- W2069841283 cites W2058052041 @default.
- W2069841283 cites W2063360787 @default.
- W2069841283 cites W2070669906 @default.
- W2069841283 cites W2074093254 @default.
- W2069841283 cites W2093804110 @default.
- W2069841283 cites W2106140689 @default.
- W2069841283 cites W2128402268 @default.
- W2069841283 cites W2131288855 @default.
- W2069841283 cites W2131377165 @default.
- W2069841283 cites W2147993766 @default.
- W2069841283 cites W2156879354 @default.
- W2069841283 doi "https://doi.org/10.1248/bpb.33.1639" @default.
- W2069841283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20930369" @default.
- W2069841283 hasPublicationYear "2010" @default.
- W2069841283 type Work @default.
- W2069841283 sameAs 2069841283 @default.
- W2069841283 citedByCount "4" @default.
- W2069841283 countsByYear W20698412832013 @default.
- W2069841283 countsByYear W20698412832015 @default.
- W2069841283 countsByYear W20698412832021 @default.
- W2069841283 crossrefType "journal-article" @default.
- W2069841283 hasAuthorship W2069841283A5028837265 @default.
- W2069841283 hasAuthorship W2069841283A5065081352 @default.
- W2069841283 hasAuthorship W2069841283A5077581823 @default.
- W2069841283 hasBestOaLocation W20698412831 @default.
- W2069841283 hasConcept C104317684 @default.
- W2069841283 hasConcept C119157956 @default.
- W2069841283 hasConcept C134651460 @default.
- W2069841283 hasConcept C181199279 @default.
- W2069841283 hasConcept C182516595 @default.
- W2069841283 hasConcept C185592680 @default.
- W2069841283 hasConcept C197957613 @default.
- W2069841283 hasConcept C2778328694 @default.
- W2069841283 hasConcept C2778340702 @default.
- W2069841283 hasConcept C2778470496 @default.
- W2069841283 hasConcept C2779123261 @default.
- W2069841283 hasConcept C2779649592 @default.
- W2069841283 hasConcept C2781338088 @default.
- W2069841283 hasConcept C31258907 @default.
- W2069841283 hasConcept C41008148 @default.
- W2069841283 hasConcept C55493867 @default.
- W2069841283 hasConcept C71240020 @default.
- W2069841283 hasConceptScore W2069841283C104317684 @default.
- W2069841283 hasConceptScore W2069841283C119157956 @default.
- W2069841283 hasConceptScore W2069841283C134651460 @default.
- W2069841283 hasConceptScore W2069841283C181199279 @default.
- W2069841283 hasConceptScore W2069841283C182516595 @default.
- W2069841283 hasConceptScore W2069841283C185592680 @default.
- W2069841283 hasConceptScore W2069841283C197957613 @default.
- W2069841283 hasConceptScore W2069841283C2778328694 @default.
- W2069841283 hasConceptScore W2069841283C2778340702 @default.
- W2069841283 hasConceptScore W2069841283C2778470496 @default.
- W2069841283 hasConceptScore W2069841283C2779123261 @default.
- W2069841283 hasConceptScore W2069841283C2779649592 @default.
- W2069841283 hasConceptScore W2069841283C2781338088 @default.
- W2069841283 hasConceptScore W2069841283C31258907 @default.
- W2069841283 hasConceptScore W2069841283C41008148 @default.
- W2069841283 hasConceptScore W2069841283C55493867 @default.
- W2069841283 hasConceptScore W2069841283C71240020 @default.
- W2069841283 hasIssue "10" @default.
- W2069841283 hasLocation W20698412831 @default.
- W2069841283 hasLocation W20698412832 @default.
- W2069841283 hasOpenAccess W2069841283 @default.
- W2069841283 hasPrimaryLocation W20698412831 @default.
- W2069841283 hasRelatedWork W2018126395 @default.
- W2069841283 hasRelatedWork W2033844980 @default.
- W2069841283 hasRelatedWork W2048631858 @default.
- W2069841283 hasRelatedWork W2069841283 @default.
- W2069841283 hasRelatedWork W2111059729 @default.
- W2069841283 hasRelatedWork W2118375848 @default.
- W2069841283 hasRelatedWork W2118800463 @default.
- W2069841283 hasRelatedWork W2148815054 @default.
- W2069841283 hasRelatedWork W2151443151 @default.
- W2069841283 hasRelatedWork W226918682 @default.
- W2069841283 hasVolume "33" @default.
- W2069841283 isParatext "false" @default.
- W2069841283 isRetracted "false" @default.
- W2069841283 magId "2069841283" @default.
- W2069841283 workType "article" @default.