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• W2069848841 endingPage "574" @default.
• W2069848841 startingPage "539" @default.
• W2069848841 abstract "This chapter summarizes classical knowledge and recent advances in the release of neurotransmitters, emphasizing evidence supporting present concepts, rather than a recitation of dogma. Topics covered include:•Structural organization of chemical synapses•Quantal nature of transmission; identification of the synaptic vesicle as the physical quantum•Vesicle membrane and transmitter cycles•Biophysics of excitation-secretion coupling; secretory trigger properties•Calcium microdomains in triggering exocytosis•Mobilizing vesicles to docking sites and priming vesicles for release•Presynaptic protein identification by vesicle purification and genetics•SNARE proteins: assembly, disassembly, and vesicle fusion•Synaptotagmin: calcium sensor and secretory trigger•Docking and priming proteins•Molecular mechanisms of endocytosis and vesicle refilling•Quantal analysis at neuromuscular junctions and central synapses•Poisson and binomial models; meaning of statistical parameters•Limitations of the standard Katz model•Single and multivesicular release at active zones•Spontaneous vs. evoked release•Estimating and manipulating statistical parameters•Quantal analysis of release modulation" @default.
• W2069848841 created "2016-06-24" @default.
• W2069848841 creator A5013232203 @default.
• W2069848841 creator A5026872836 @default.
• W2069848841 creator A5077104196 @default.
• W2069848841 date "1994-03-01" @default.
• W2069848841 modified "2023-10-18" @default.
• W2069848841 title "Presynaptic plasticity: The regulation of Ca2+-dependent transmitter release" @default.
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