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• W2069851047 abstract "Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule. In all of these tumors, beta 2m protein and mRNA were found to be completely absent from the neoplastic cells, whereas free H chains and their respective mRNAs were present in abundance in the tumor cell cytoplasm. The selective abrogation of beta 2m expression represents a unique mechanism leading to a complete loss of class I antigen surface expression in vivo." @default.
• W2069851047 created "2016-06-24" @default.
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• W2069851047 date "1989-01-01" @default.
• W2069851047 modified "2023-10-01" @default.
• W2069851047 title "Selective loss of beta 2-microglobulin mRNA in human colon carcinoma." @default.
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• W2069851047 doi "https://doi.org/10.1084/jem.169.1.309" @default.
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