Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069852032> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2069852032 endingPage "612" @default.
- W2069852032 startingPage "604" @default.
- W2069852032 abstract "Background Several types of viral-transduced HER2/neu-modified dendritic cells (DCHER2/neu) have been used for preventing and/or treating HER2/neu-overexpressing tumors. However, to date, lentivirus has not been used to generate HER2/neu-modified DCs. Methods In the present study, we used recombinant lentivirus containing a truncated neu gene (rLVneu) to transduce murine bone marrow-derived dendritic cells and investigated their preventive and therapeutic effects on HER2/neu-overexpressing tumors. Results The data obtained show that a single low dose of lentiviral-transduced DCHER2/neu could significantly elevate serum anti-neu antibody level, stimulate the proliferation of CD4 and CD8 T lymphocytes and interferon-γ secretion, induce a long lasting preventive effect against HER2/neu-overexpressing tumors and significantly suppress the growth of established HER2/neu-overexpressing tumors. Conclusions The present study demonstrates that a single low dose of DCs modified with rLV containing a truncated neu oncogene can achieve a strong and long lasting effect on neu-overexpressing tumors, suggesting the possible clinical application of this strategy. Copyright © 2010 John Wiley & Sons, Ltd." @default.
- W2069852032 created "2016-06-24" @default.
- W2069852032 creator A5000026105 @default.
- W2069852032 creator A5068012990 @default.
- W2069852032 date "2010-06-08" @default.
- W2069852032 modified "2023-09-27" @default.
- W2069852032 title "A single low dose of dendritic cells modified with lentivirus containing a truncated neu gene can effectively suppress neu-overexpressing tumors" @default.
- W2069852032 cites W1661544713 @default.
- W2069852032 cites W1981259148 @default.
- W2069852032 cites W1982438873 @default.
- W2069852032 cites W1998144917 @default.
- W2069852032 cites W2009070325 @default.
- W2069852032 cites W2009761723 @default.
- W2069852032 cites W2009985995 @default.
- W2069852032 cites W2015078106 @default.
- W2069852032 cites W2047368369 @default.
- W2069852032 cites W2054512182 @default.
- W2069852032 cites W2058963225 @default.
- W2069852032 cites W2063339404 @default.
- W2069852032 cites W2092235636 @default.
- W2069852032 cites W2095156669 @default.
- W2069852032 cites W2110442763 @default.
- W2069852032 cites W2159363679 @default.
- W2069852032 cites W2165537599 @default.
- W2069852032 doi "https://doi.org/10.1002/jgm.1475" @default.
- W2069852032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20533530" @default.
- W2069852032 hasPublicationYear "2010" @default.
- W2069852032 type Work @default.
- W2069852032 sameAs 2069852032 @default.
- W2069852032 citedByCount "3" @default.
- W2069852032 countsByYear W20698520322012 @default.
- W2069852032 countsByYear W20698520322013 @default.
- W2069852032 countsByYear W20698520322014 @default.
- W2069852032 crossrefType "journal-article" @default.
- W2069852032 hasAuthorship W2069852032A5000026105 @default.
- W2069852032 hasAuthorship W2069852032A5068012990 @default.
- W2069852032 hasConcept C104317684 @default.
- W2069852032 hasConcept C121608353 @default.
- W2069852032 hasConcept C153911025 @default.
- W2069852032 hasConcept C167672396 @default.
- W2069852032 hasConcept C185592680 @default.
- W2069852032 hasConcept C203014093 @default.
- W2069852032 hasConcept C2522874641 @default.
- W2069852032 hasConcept C2776872082 @default.
- W2069852032 hasConcept C2778170410 @default.
- W2069852032 hasConcept C2779690655 @default.
- W2069852032 hasConcept C2780727368 @default.
- W2069852032 hasConcept C32470452 @default.
- W2069852032 hasConcept C40767141 @default.
- W2069852032 hasConcept C502942594 @default.
- W2069852032 hasConcept C530470458 @default.
- W2069852032 hasConcept C54355233 @default.
- W2069852032 hasConcept C86803240 @default.
- W2069852032 hasConcept C8891405 @default.
- W2069852032 hasConceptScore W2069852032C104317684 @default.
- W2069852032 hasConceptScore W2069852032C121608353 @default.
- W2069852032 hasConceptScore W2069852032C153911025 @default.
- W2069852032 hasConceptScore W2069852032C167672396 @default.
- W2069852032 hasConceptScore W2069852032C185592680 @default.
- W2069852032 hasConceptScore W2069852032C203014093 @default.
- W2069852032 hasConceptScore W2069852032C2522874641 @default.
- W2069852032 hasConceptScore W2069852032C2776872082 @default.
- W2069852032 hasConceptScore W2069852032C2778170410 @default.
- W2069852032 hasConceptScore W2069852032C2779690655 @default.
- W2069852032 hasConceptScore W2069852032C2780727368 @default.
- W2069852032 hasConceptScore W2069852032C32470452 @default.
- W2069852032 hasConceptScore W2069852032C40767141 @default.
- W2069852032 hasConceptScore W2069852032C502942594 @default.
- W2069852032 hasConceptScore W2069852032C530470458 @default.
- W2069852032 hasConceptScore W2069852032C54355233 @default.
- W2069852032 hasConceptScore W2069852032C86803240 @default.
- W2069852032 hasConceptScore W2069852032C8891405 @default.
- W2069852032 hasIssue "7" @default.
- W2069852032 hasLocation W20698520321 @default.
- W2069852032 hasLocation W20698520322 @default.
- W2069852032 hasOpenAccess W2069852032 @default.
- W2069852032 hasPrimaryLocation W20698520321 @default.
- W2069852032 hasRelatedWork W2069852032 @default.
- W2069852032 hasRelatedWork W2298489141 @default.
- W2069852032 hasRelatedWork W2354296025 @default.
- W2069852032 hasRelatedWork W2355046842 @default.
- W2069852032 hasRelatedWork W2357779750 @default.
- W2069852032 hasRelatedWork W2359135008 @default.
- W2069852032 hasRelatedWork W2364889042 @default.
- W2069852032 hasRelatedWork W2376914061 @default.
- W2069852032 hasRelatedWork W2385797964 @default.
- W2069852032 hasRelatedWork W3031184807 @default.
- W2069852032 hasVolume "12" @default.
- W2069852032 isParatext "false" @default.
- W2069852032 isRetracted "false" @default.
- W2069852032 magId "2069852032" @default.
- W2069852032 workType "article" @default.