FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069852766> ?p ?o ?g. }

• W2069852766 endingPage "595" @default.
• W2069852766 startingPage "589" @default.
• W2069852766 abstract "Background Mannose binding lectin (MBL) is a key mediator of both innate immunity and efferocytosis (phagocytosis of apoptotic cells) in the airway. Defective efferocytosis results in a net increase in apoptotic material that can undergo secondary necrosis, leading to tissue damage and chronic inflammation. We have shown reduced MBL and efferocytosis in other chronic inflammatory lung diseases; we therefore hypothesized that reduced MBL and efferocytosis in the airways may be a determinant of bronchiolitis obliterans syndrome (BOS) after lung transplantation. Methods We investigated MBL (enzyme-linked immunosorbent assay [ELISA]), MBL-mediated complement deposition (UC4, ELISA), and efferocytosis of apoptotic bronchial epithelial cells (flow cytometry) in bronchoalveolar lavage (BAL) and peripheral blood from 75 lung transplant recipients, comprising 16 with stable graft function, 34 stable with proven infection, 25 with BOS, and 14 healthy controls. Results In plasma, MBL levels were highly variable (0–17.538 μg/ml), but increased in infected patients vs control (p = 0.09) or stable groups (p = 0.003). There was a similar increase in UC4 in infected patients and a significant correlation between MBL and UC4. There was no correlation between MBL and time after transplant. In BAL, MBL levels were less variable (0–73.3 ng/ml) and significantly reduced in patients with BOS vs controls and stable groups. Efferocytosis was significantly reduced in the BOS group vs control and stable groups (mean [SEM] control, 20% [1.3%]; stable, 20.5% [2.5%]; infected, 17.3% [2.8%]; BOS, 11.3% [1.5%], p = 0.04). Conclusions Low levels of MBL in the airway may play a role in reduced efferocytosis, subsequent tissue damage, and BOS after lung transplantation. Mannose binding lectin (MBL) is a key mediator of both innate immunity and efferocytosis (phagocytosis of apoptotic cells) in the airway. Defective efferocytosis results in a net increase in apoptotic material that can undergo secondary necrosis, leading to tissue damage and chronic inflammation. We have shown reduced MBL and efferocytosis in other chronic inflammatory lung diseases; we therefore hypothesized that reduced MBL and efferocytosis in the airways may be a determinant of bronchiolitis obliterans syndrome (BOS) after lung transplantation. We investigated MBL (enzyme-linked immunosorbent assay [ELISA]), MBL-mediated complement deposition (UC4, ELISA), and efferocytosis of apoptotic bronchial epithelial cells (flow cytometry) in bronchoalveolar lavage (BAL) and peripheral blood from 75 lung transplant recipients, comprising 16 with stable graft function, 34 stable with proven infection, 25 with BOS, and 14 healthy controls. In plasma, MBL levels were highly variable (0–17.538 μg/ml), but increased in infected patients vs control (p = 0.09) or stable groups (p = 0.003). There was a similar increase in UC4 in infected patients and a significant correlation between MBL and UC4. There was no correlation between MBL and time after transplant. In BAL, MBL levels were less variable (0–73.3 ng/ml) and significantly reduced in patients with BOS vs controls and stable groups. Efferocytosis was significantly reduced in the BOS group vs control and stable groups (mean [SEM] control, 20% [1.3%]; stable, 20.5% [2.5%]; infected, 17.3% [2.8%]; BOS, 11.3% [1.5%], p = 0.04). Low levels of MBL in the airway may play a role in reduced efferocytosis, subsequent tissue damage, and BOS after lung transplantation." @default.
• W2069852766 created "2016-06-24" @default.
• W2069852766 creator A5026818455 @default.
• W2069852766 creator A5048322411 @default.
• W2069852766 creator A5053433505 @default.
• W2069852766 creator A5060644052 @default.
• W2069852766 creator A5068465959 @default.
• W2069852766 date "2011-05-01" @default.
• W2069852766 modified "2023-10-14" @default.
• W2069852766 title "Decreased efferocytosis and mannose binding lectin in the airway in bronchiolitis obliterans syndrome" @default.
• W2069852766 cites W1540354887 @default.
• W2069852766 cites W1630503232 @default.
• W2069852766 cites W1961991439 @default.
• W2069852766 cites W1965845686 @default.
• W2069852766 cites W1980191732 @default.
• W2069852766 cites W1981188222 @default.
• W2069852766 cites W1983389272 @default.
• W2069852766 cites W1983791133 @default.
• W2069852766 cites W1984329347 @default.
• W2069852766 cites W1996168515 @default.
• W2069852766 cites W2011709265 @default.
• W2069852766 cites W2020340107 @default.
• W2069852766 cites W2037402548 @default.
• W2069852766 cites W2040177881 @default.
• W2069852766 cites W2048327821 @default.
• W2069852766 cites W2054515658 @default.
• W2069852766 cites W2058853575 @default.
• W2069852766 cites W2064294897 @default.
• W2069852766 cites W2072542018 @default.
• W2069852766 cites W2086309846 @default.
• W2069852766 cites W2098499248 @default.
• W2069852766 cites W2098582660 @default.
• W2069852766 cites W2111806738 @default.
• W2069852766 cites W2113554363 @default.
• W2069852766 cites W2123000331 @default.
• W2069852766 cites W2132984312 @default.
• W2069852766 cites W2142216001 @default.
• W2069852766 cites W2145621175 @default.
• W2069852766 cites W2146484777 @default.
• W2069852766 cites W2147593846 @default.
• W2069852766 cites W2151568144 @default.
• W2069852766 cites W2158803364 @default.
• W2069852766 cites W2160505373 @default.
• W2069852766 cites W2160947470 @default.
• W2069852766 cites W2168418918 @default.
• W2069852766 cites W2766892013 @default.
• W2069852766 cites W4251364816 @default.
• W2069852766 doi "https://doi.org/10.1016/j.healun.2011.01.710" @default.
• W2069852766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21481686" @default.
• W2069852766 hasPublicationYear "2011" @default.
• W2069852766 type Work @default.
• W2069852766 sameAs 2069852766 @default.
• W2069852766 citedByCount "24" @default.
• W2069852766 countsByYear W20698527662012 @default.
• W2069852766 countsByYear W20698527662013 @default.
• W2069852766 countsByYear W20698527662014 @default.
• W2069852766 countsByYear W20698527662015 @default.
• W2069852766 countsByYear W20698527662016 @default.
• W2069852766 countsByYear W20698527662017 @default.
• W2069852766 countsByYear W20698527662018 @default.
• W2069852766 countsByYear W20698527662019 @default.
• W2069852766 countsByYear W20698527662020 @default.
• W2069852766 countsByYear W20698527662021 @default.
• W2069852766 countsByYear W20698527662022 @default.
• W2069852766 crossrefType "journal-article" @default.
• W2069852766 hasAuthorship W2069852766A5026818455 @default.
• W2069852766 hasAuthorship W2069852766A5048322411 @default.
• W2069852766 hasAuthorship W2069852766A5053433505 @default.
• W2069852766 hasAuthorship W2069852766A5060644052 @default.
• W2069852766 hasAuthorship W2069852766A5068465959 @default.
• W2069852766 hasBestOaLocation W20698527662 @default.
• W2069852766 hasConcept C126322002 @default.
• W2069852766 hasConcept C168261976 @default.
• W2069852766 hasConcept C189413060 @default.
• W2069852766 hasConcept C202751555 @default.
• W2069852766 hasConcept C203014093 @default.
• W2069852766 hasConcept C2776252253 @default.
• W2069852766 hasConcept C2776727875 @default.
• W2069852766 hasConcept C2776739411 @default.
• W2069852766 hasConcept C2776914184 @default.
• W2069852766 hasConcept C2777677276 @default.
• W2069852766 hasConcept C2777714996 @default.
• W2069852766 hasConcept C2777961210 @default.
• W2069852766 hasConcept C2779244956 @default.
• W2069852766 hasConcept C2780758401 @default.
• W2069852766 hasConcept C2781142857 @default.
• W2069852766 hasConcept C2781448352 @default.
• W2069852766 hasConcept C553184892 @default.
• W2069852766 hasConcept C55493867 @default.
• W2069852766 hasConcept C71924100 @default.
• W2069852766 hasConcept C86803240 @default.
• W2069852766 hasConceptScore W2069852766C126322002 @default.
• W2069852766 hasConceptScore W2069852766C168261976 @default.
• W2069852766 hasConceptScore W2069852766C189413060 @default.
• W2069852766 hasConceptScore W2069852766C202751555 @default.
• W2069852766 hasConceptScore W2069852766C203014093 @default.
• W2069852766 hasConceptScore W2069852766C2776252253 @default.
• W2069852766 hasConceptScore W2069852766C2776727875 @default.

• next