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• W2069854718 abstract "Renal handling of calcium and phosphate during mineralocorticoid escape in man. Previous work in animals and man suggests a close relationship between sodium and phosphate reabsorption in proximal tubule, and between sodium and calcium in the proximal tubule and the distal nephron; hence, decreased sodium transport in the proximal tubule may be associated with phosphaturia since phosphate is mostly unreabsorbed distally, while decreased sodium reabsorption in the distal tubules may occur with calciuria only. The sites and the renal mechanisms of mineralocorticoid escape were studied by Na, Ca and P balance and clearance methods in seven patients with primary aldosteronism (aldos) and in three normal subjects. In both groups, when Na intake was raised or lowered over a range of 20 to 200 mEq/day, Ca clearance (C Ca ) varied with C Na (r = 0.8, P Ca /ΔC Na was higher (P Ca was not different in the two groups, whereas at dietary Na of 200 mEq, C Ca was higher (P Na was similar in the two groups. In contrast to C Ca , C p did not vary with C Na in either group at any level of Na intake. Data suggest: 1) renal adjustments to dietary Na occur mainly in the distal nephron in both groups, since changes in C Na were accompanied by changes in C Ca but not C p ; 2) aldosterone escape occurs with hypercalciuria and results from decreased distal reabsorption at sites (insensitive to aldosterone) where Na and Ca are closely linked; 3) in normal subjects, distal tubular sodium adjustments occur at both the latter site and an aldo-sensitive site where Na and Ca are not linked." @default.
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• W2069854718 date "1972-11-01" @default.
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• W2069854718 title "Renal handling of calcium and phosphate during mineralocorticoid “escape” in man" @default.
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• W2069854718 doi "https://doi.org/10.1038/ki.1972.107" @default.
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