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- W2069875203 abstract "Lantibiotics are small peptides produced by Gram-positive bacteria, which are ribosomally synthesized as a prepeptide. Their genes are highly organized in operons containing all the genes required for maturation, transport, immunity and synthesis. The best-characterized lantibiotic is nisin from Lactococcus lactis. Nisin is active against other Gram-positive bacteria via various modes of actions. To prevent activity against its producer strain, an autoimmunity system has developed consisting of different proteins, the ABC transporter NisFEG and a membrane anchored protein NisI. Together, they circumvent the ability of nisin to fulfill its action and cause cell death of L. lactis. Within this review, the mechanism of regulation, biosynthesis and activity of the immunity machinery will be discussed. Furthermore a short description about the application of these immunity proteins in both medical and industrial fields is highlighted." @default.
- W2069875203 created "2016-06-24" @default.
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- W2069875203 creator A5077256764 @default.
- W2069875203 creator A5085241843 @default.
- W2069875203 date "2012-06-01" @default.
- W2069875203 modified "2023-10-14" @default.
- W2069875203 title "Lantibiotics: How do producers become self-protected?" @default.
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- W2069875203 doi "https://doi.org/10.1016/j.jbiotec.2012.01.032" @default.
- W2069875203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22329892" @default.
- W2069875203 hasPublicationYear "2012" @default.
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