Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069879582> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2069879582 endingPage "123" @default.
- W2069879582 startingPage "116" @default.
- W2069879582 abstract "To determine the overall incidence of isoniazid (INH) hepatotoxicity in a public health tuberculosis clinic over a 7-year period, and to determine if systematic, limited aspartate aminotransferase (AST) monitoring would be of benefit in detecting INH hepatotoxicity.Evaluation of INH hepatotoxicity in adults aged > or = 25 years from a database maintained from fall 1996 to 2003 in a public health department clinic. Hepatotoxicity was defined as AST levels more than five times the upper limit of normal (ULN).Among 3,377 patients started on INH therapy, 19 patients had AST levels more than five times the ULN, or a rate of 5.6 per 1,000 patients. Only 1 of 19 patients had prodromal symptoms associated with hepatotoxicity. After 1 month, 3 months, and 6 months of therapy, the numbers of hepatotoxic events per 1,000 patients were 2.75, 7.20, and 4.10. The age-specific numbers of hepatotoxic events per 1,000 patients were 4.40 for those from 25 to 34 years of age, inclusive; 8.54 for those between 35 to 49 years of age, inclusive; and 20.83 for those > or = 50 years old. Age > 49 years (p < 0.02) and baseline AST greater than ULN (p < 0.0003) were risk factors for hepatotoxicity.Consistent with earlier trials, INH hepatoxicity is age related. Our results suggest hepatotoxicity is also related to baseline AST greater than ULN. Moderate-to-severe hepatotoxicity frequently occurs without symptoms, suggesting the value of more widespread AST monitoring." @default.
- W2069879582 created "2016-06-24" @default.
- W2069879582 creator A5001723510 @default.
- W2069879582 creator A5002950940 @default.
- W2069879582 creator A5017602824 @default.
- W2069879582 creator A5076509098 @default.
- W2069879582 date "2005-07-01" @default.
- W2069879582 modified "2023-10-18" @default.
- W2069879582 title "Isoniazid Hepatotoxicity Associated With Treatment of Latent Tuberculosis Infection" @default.
- W2069879582 cites W1875469629 @default.
- W2069879582 cites W2020332357 @default.
- W2069879582 cites W2034524018 @default.
- W2069879582 cites W2037537545 @default.
- W2069879582 cites W2057269831 @default.
- W2069879582 cites W2064727915 @default.
- W2069879582 cites W2078280751 @default.
- W2069879582 cites W2100015029 @default.
- W2069879582 cites W2123876596 @default.
- W2069879582 cites W2135798575 @default.
- W2069879582 cites W2151990581 @default.
- W2069879582 cites W2263614100 @default.
- W2069879582 cites W2418210342 @default.
- W2069879582 cites W26625382 @default.
- W2069879582 cites W4238828462 @default.
- W2069879582 doi "https://doi.org/10.1378/chest.128.1.116" @default.
- W2069879582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16002924" @default.
- W2069879582 hasPublicationYear "2005" @default.
- W2069879582 type Work @default.
- W2069879582 sameAs 2069879582 @default.
- W2069879582 citedByCount "231" @default.
- W2069879582 countsByYear W20698795822012 @default.
- W2069879582 countsByYear W20698795822013 @default.
- W2069879582 countsByYear W20698795822014 @default.
- W2069879582 countsByYear W20698795822015 @default.
- W2069879582 countsByYear W20698795822016 @default.
- W2069879582 countsByYear W20698795822017 @default.
- W2069879582 countsByYear W20698795822018 @default.
- W2069879582 countsByYear W20698795822019 @default.
- W2069879582 countsByYear W20698795822020 @default.
- W2069879582 countsByYear W20698795822021 @default.
- W2069879582 countsByYear W20698795822022 @default.
- W2069879582 countsByYear W20698795822023 @default.
- W2069879582 crossrefType "journal-article" @default.
- W2069879582 hasAuthorship W2069879582A5001723510 @default.
- W2069879582 hasAuthorship W2069879582A5002950940 @default.
- W2069879582 hasAuthorship W2069879582A5017602824 @default.
- W2069879582 hasAuthorship W2069879582A5076509098 @default.
- W2069879582 hasConcept C120665830 @default.
- W2069879582 hasConcept C121332964 @default.
- W2069879582 hasConcept C126322002 @default.
- W2069879582 hasConcept C142724271 @default.
- W2069879582 hasConcept C187212893 @default.
- W2069879582 hasConcept C2776967927 @default.
- W2069879582 hasConcept C2781069245 @default.
- W2069879582 hasConcept C61511704 @default.
- W2069879582 hasConcept C71924100 @default.
- W2069879582 hasConcept C90924648 @default.
- W2069879582 hasConceptScore W2069879582C120665830 @default.
- W2069879582 hasConceptScore W2069879582C121332964 @default.
- W2069879582 hasConceptScore W2069879582C126322002 @default.
- W2069879582 hasConceptScore W2069879582C142724271 @default.
- W2069879582 hasConceptScore W2069879582C187212893 @default.
- W2069879582 hasConceptScore W2069879582C2776967927 @default.
- W2069879582 hasConceptScore W2069879582C2781069245 @default.
- W2069879582 hasConceptScore W2069879582C61511704 @default.
- W2069879582 hasConceptScore W2069879582C71924100 @default.
- W2069879582 hasConceptScore W2069879582C90924648 @default.
- W2069879582 hasIssue "1" @default.
- W2069879582 hasLocation W20698795821 @default.
- W2069879582 hasLocation W20698795822 @default.
- W2069879582 hasOpenAccess W2069879582 @default.
- W2069879582 hasPrimaryLocation W20698795821 @default.
- W2069879582 hasRelatedWork W1835822543 @default.
- W2069879582 hasRelatedWork W1904509274 @default.
- W2069879582 hasRelatedWork W2000611000 @default.
- W2069879582 hasRelatedWork W2005026657 @default.
- W2069879582 hasRelatedWork W2089622609 @default.
- W2069879582 hasRelatedWork W2111693775 @default.
- W2069879582 hasRelatedWork W233715507 @default.
- W2069879582 hasRelatedWork W2351859577 @default.
- W2069879582 hasRelatedWork W2374306806 @default.
- W2069879582 hasRelatedWork W2432463313 @default.
- W2069879582 hasVolume "128" @default.
- W2069879582 isParatext "false" @default.
- W2069879582 isRetracted "false" @default.
- W2069879582 magId "2069879582" @default.
- W2069879582 workType "article" @default.