FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069881405> ?p ?o ?g. }

• W2069881405 endingPage "203" @default.
• W2069881405 startingPage "195" @default.
• W2069881405 abstract "The vasomotor and cyclic GMP-elevating activity of YC-1, a novel NO-independent activator of soluble guanylyl cyclase (sGC), was studied in isolated rabbit aortic rings and compared to that of the NO donor compounds sodium nitroprusside (SNP) and NOC 18. Similarly to SNP and NOC 18, YC-1 (0.3-300 microM) caused a concentration-dependent, endothelium-independent relaxation that was greatly reduced by the sGC inhibitor 1-H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one (ODQ 10 microM; 59% inhibition of dilation induced by 100 microM YC-1) suggesting the activation of sGC as one mechanism of action. Preincubation with YC-1 (3 and 30 microM) significantly increased the maximal dilator responses mediated by endogenous NO in aortic rings that was released upon exposure to acetylcholine, and enhanced the dilator response to the exogenous NO-donors, SNP and NOC 18, by almost two orders of magnitude. Vasoactivity induced by SNP and YC-1 displayed different kinetics as evidenced by a longlasting inhibition by YC-1 (300 microM) on the phenylephrine (PE)-induced contractile response, which was not fully reversible even after extensive washout (150 min) of YC-1, and was accompanied by a long-lasting elevation of intracellular cyclic GMP content. In contrast, SNP (30 microM) had no effect on the vasoconstrictor potency of PE, and increases in intravascular cyclic GMP levels were readily reversed after washout of this NO donor compound. Surprisingly, YC-1 not only activated sGC, but also affected cyclic GMP metabolism, as it inhibited both cyclic GMP break down in aortic extracts and the activity of phosphodiesterase isoforms 1-5 in vitro. In conclusion, YC-1 caused persistent elevation of intravascular cyclic GMP levels in vivo by activating sGC and inhibiting cyclic GMP break down. Thus, YC-1 is a highly effective vasodilator compound with a prolonged duration of action, and mechanisms that are unprecedented for any previously known sGC activator." @default.
• W2069881405 created "2016-06-24" @default.
• W2069881405 creator A5025375225 @default.
• W2069881405 creator A5026146238 @default.
• W2069881405 creator A5033368647 @default.
• W2069881405 creator A5039431217 @default.
• W2069881405 creator A5053274881 @default.
• W2069881405 creator A5059057183 @default.
• W2069881405 creator A5059749605 @default.
• W2069881405 date "1999-05-01" @default.
• W2069881405 modified "2023-10-17" @default.
• W2069881405 title "Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity" @default.
• W2069881405 cites W1535816350 @default.
• W2069881405 cites W1775749144 @default.
• W2069881405 cites W1875166327 @default.
• W2069881405 cites W1981046160 @default.
• W2069881405 cites W2000075945 @default.
• W2069881405 cites W2009846810 @default.
• W2069881405 cites W2013023382 @default.
• W2069881405 cites W2018360364 @default.
• W2069881405 cites W2020726609 @default.
• W2069881405 cites W2022699060 @default.
• W2069881405 cites W2028211677 @default.
• W2069881405 cites W2040072601 @default.
• W2069881405 cites W2044263892 @default.
• W2069881405 cites W2045374140 @default.
• W2069881405 cites W2051605684 @default.
• W2069881405 cites W2081394289 @default.
• W2069881405 cites W2088388769 @default.
• W2069881405 cites W2090813651 @default.
• W2069881405 cites W2107732949 @default.
• W2069881405 cites W2109654316 @default.
• W2069881405 cites W2290801290 @default.
• W2069881405 cites W2316918019 @default.
• W2069881405 cites W2405690953 @default.
• W2069881405 cites W2410310759 @default.
• W2069881405 cites W2467657054 @default.
• W2069881405 cites W2501937898 @default.
• W2069881405 cites W304581165 @default.
• W2069881405 cites W36317527 @default.
• W2069881405 cites W7189392 @default.
• W2069881405 doi "https://doi.org/10.1038/sj.bjp.0702495" @default.
• W2069881405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565982" @default.
• W2069881405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10369473" @default.
• W2069881405 hasPublicationYear "1999" @default.
• W2069881405 type Work @default.
• W2069881405 sameAs 2069881405 @default.
• W2069881405 citedByCount "161" @default.
• W2069881405 countsByYear W20698814052012 @default.
• W2069881405 countsByYear W20698814052013 @default.
• W2069881405 countsByYear W20698814052014 @default.
• W2069881405 countsByYear W20698814052015 @default.
• W2069881405 countsByYear W20698814052016 @default.
• W2069881405 countsByYear W20698814052017 @default.
• W2069881405 countsByYear W20698814052018 @default.
• W2069881405 countsByYear W20698814052019 @default.
• W2069881405 countsByYear W20698814052020 @default.
• W2069881405 countsByYear W20698814052021 @default.
• W2069881405 countsByYear W20698814052022 @default.
• W2069881405 countsByYear W20698814052023 @default.
• W2069881405 crossrefType "journal-article" @default.
• W2069881405 hasAuthorship W2069881405A5025375225 @default.
• W2069881405 hasAuthorship W2069881405A5026146238 @default.
• W2069881405 hasAuthorship W2069881405A5033368647 @default.
• W2069881405 hasAuthorship W2069881405A5039431217 @default.
• W2069881405 hasAuthorship W2069881405A5053274881 @default.
• W2069881405 hasAuthorship W2069881405A5059057183 @default.
• W2069881405 hasAuthorship W2069881405A5059749605 @default.
• W2069881405 hasBestOaLocation W20698814052 @default.
• W2069881405 hasConcept C120770815 @default.
• W2069881405 hasConcept C126322002 @default.
• W2069881405 hasConcept C134018914 @default.
• W2069881405 hasConcept C170493617 @default.
• W2069881405 hasConcept C178790620 @default.
• W2069881405 hasConcept C185592680 @default.
• W2069881405 hasConcept C2777032099 @default.
• W2069881405 hasConcept C2777952589 @default.
• W2069881405 hasConcept C2778827303 @default.
• W2069881405 hasConcept C2779610285 @default.
• W2069881405 hasConcept C3020139451 @default.
• W2069881405 hasConcept C519581460 @default.
• W2069881405 hasConcept C55493867 @default.
• W2069881405 hasConcept C71839028 @default.
• W2069881405 hasConcept C71924100 @default.
• W2069881405 hasConcept C84393581 @default.
• W2069881405 hasConcept C86803240 @default.
• W2069881405 hasConcept C88045685 @default.
• W2069881405 hasConcept C98274493 @default.
• W2069881405 hasConceptScore W2069881405C120770815 @default.
• W2069881405 hasConceptScore W2069881405C126322002 @default.
• W2069881405 hasConceptScore W2069881405C134018914 @default.
• W2069881405 hasConceptScore W2069881405C170493617 @default.
• W2069881405 hasConceptScore W2069881405C178790620 @default.
• W2069881405 hasConceptScore W2069881405C185592680 @default.
• W2069881405 hasConceptScore W2069881405C2777032099 @default.
• W2069881405 hasConceptScore W2069881405C2777952589 @default.
• W2069881405 hasConceptScore W2069881405C2778827303 @default.
• W2069881405 hasConceptScore W2069881405C2779610285 @default.

• next