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• W2069882662 startingPage "784" @default.
• W2069882662 abstract "Purpose To examine the potential of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for differential diagnosis of head and neck cancer. Methods and materials DCE-MRI was performed in 26 patients with untreated squamous cell carcinoma (SCC), 28 undifferentiated carcinoma (UD) and 8 lymphoma. DCE-MRI was analyzed with the pharmacokinetic model proposed by Tofts and Kermode to produce the three DCE parameters: ktrans, v e and v p . Areas under the curve (AUC) at the initial 60 and 90 s (AUC60 and AUC90) were also recorded. Histogram analysis was conducted to obtain the mean, 25%, 50%, 75% and 95% percentile values and the Kruskal–Wallis test was used to compare the DCE parameters between the three groups of cancer. Results ktrans, AUC60 and AUC90 showed significant differences (p < 0.01) between UD/SCC and UD/lymphoma, but not between SCC/lymphoma. The mean AUC90 demonstrated the highest accuracy of 78% (sensitivity of 68% and specificity of 88%) for distinguishing UD and SCC, and the 75% percentile AUC90 provided the highest accuracy of 97% (sensitivity of 100% and specificity of 88.5%) for distinguishing UD and lymphoma. Conclusions There are significant differences in the DCE parameters which show the potential for distinguishing UD from SCC or lymphoma." @default.
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• W2069882662 date "2012-04-01" @default.
• W2069882662 modified "2023-10-14" @default.
• W2069882662 title "Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) for differential diagnosis in head and neck cancers" @default.
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• W2069882662 doi "https://doi.org/10.1016/j.ejrad.2011.01.089" @default.
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