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• W2069884282 abstract "The effect of local anesthetic-like antiarrhytmic drugs on the sodium current of cardiac cells is briefly reviewed. A molecular model on the action of these drugs is formulated: the drugs can interact with the sodium channels in the rested, activated and inactivated states, and each of these interactions is characterized by an association and dissociation rate constant. The inactivation curve of drug-associated channels is shifted to more negative potentials. The model can be applied to any mechanism of excitation that accurately simulates voltage and time dependency of the sodium channels. It simulates the actions of widely differing antiarrhytmic agents such as quinidine and lidocaine, at various driving rates, rythms and membrane potentials. A biophysical interpretation of the model is proposed." @default.
• W2069884282 created "2016-06-24" @default.
• W2069884282 creator A5016638344 @default.
• W2069884282 creator A5069126018 @default.
• W2069884282 date "1977-11-01" @default.
• W2069884282 modified "2023-10-07" @default.
• W2069884282 title "Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels" @default.
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• W2069884282 doi "https://doi.org/10.1016/0304-4157(77)90003-x" @default.
• W2069884282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/334262" @default.
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