Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069884888> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2069884888 endingPage "322" @default.
- W2069884888 startingPage "317" @default.
- W2069884888 abstract "We report the results of an open multicenter study which evaluated the efficacy, safety, and tolerability of simvastatin in a large cohort of patients with primary hypercholesterolemia. Against a background of standard dietary advice, the study enrolled 595 patients with total cholesterol > or = 6.5 mmol/l and triglycerides < 6.0 mmol/l across 20 centers. After 4 weeks on placebo, treatment began with simvastatin 10 mg each night, titrating to 20 mg after 6 weeks, and then to 40 mg after 12 weeks if cholesterol levels still exceeded 5.5 mmol/l. By Week 18, 70% of patients were using 40 mg/day. After 18 weeks of treatment, the mean reductions (95% confidence interval) in total and low density lipoprotein (LDL) cholesterol were 30% (29-31%) and 38% (37-39%), respectively. There was a mean increase in high density lipoprotein (HDL) cholesterol of 12% (10-13%), while triglycerides were reduced by a median 19% (16-23%). From a mean entry total cholesterol of 9.31 +/- 2.15 mmol/l, 52% of patients achieved cholesterol levels < or = 6.2 mmol/l on treatment. The changes noted were essentially independent of gender, age, or lipid phenotype (IIa vs. IIb). Compliance with prescribed medication was very good and the drug was well tolerated; only 3% of patients manifested a clinical adverse experience requiring discontinuation or a clinical adverse experience described as serious (associated with hospitalization or serious disability). Isolated laboratory adverse experience required discontinuation in 0.2% of patients. One in 3 patients manifested a clinical adverse experience and 1 in 10 a laboratory adverse experience.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2069884888 created "2016-06-24" @default.
- W2069884888 creator A5065292569 @default.
- W2069884888 date "1993-04-01" @default.
- W2069884888 modified "2023-09-25" @default.
- W2069884888 title "Simvastatin in severe primary hypercholesterolemia: Efficacy, safety, and tolerability in 595 patients over 18 weeks" @default.
- W2069884888 cites W1946263363 @default.
- W2069884888 cites W1982536995 @default.
- W2069884888 cites W1984522052 @default.
- W2069884888 cites W1989046290 @default.
- W2069884888 cites W1995069196 @default.
- W2069884888 cites W2016678257 @default.
- W2069884888 cites W2029833995 @default.
- W2069884888 cites W2051428047 @default.
- W2069884888 cites W2055134345 @default.
- W2069884888 cites W2055561625 @default.
- W2069884888 cites W2067635119 @default.
- W2069884888 cites W2074952715 @default.
- W2069884888 cites W2089648098 @default.
- W2069884888 cites W2118313918 @default.
- W2069884888 cites W2317657624 @default.
- W2069884888 cites W2324712847 @default.
- W2069884888 cites W2331959986 @default.
- W2069884888 cites W2408671377 @default.
- W2069884888 cites W2411467835 @default.
- W2069884888 cites W2418964789 @default.
- W2069884888 cites W4240553663 @default.
- W2069884888 cites W4248137340 @default.
- W2069884888 cites W4317564062 @default.
- W2069884888 doi "https://doi.org/10.1002/clc.4960160406" @default.
- W2069884888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8458112" @default.
- W2069884888 hasPublicationYear "1993" @default.
- W2069884888 type Work @default.
- W2069884888 sameAs 2069884888 @default.
- W2069884888 citedByCount "10" @default.
- W2069884888 crossrefType "journal-article" @default.
- W2069884888 hasAuthorship W2069884888A5065292569 @default.
- W2069884888 hasBestOaLocation W20698848881 @default.
- W2069884888 hasConcept C126322002 @default.
- W2069884888 hasConcept C142724271 @default.
- W2069884888 hasConcept C197934379 @default.
- W2069884888 hasConcept C204787440 @default.
- W2069884888 hasConcept C27081682 @default.
- W2069884888 hasConcept C2776329913 @default.
- W2069884888 hasConcept C2778163477 @default.
- W2069884888 hasConcept C2778375690 @default.
- W2069884888 hasConcept C2778715236 @default.
- W2069884888 hasConcept C44249647 @default.
- W2069884888 hasConcept C71924100 @default.
- W2069884888 hasConcept C90924648 @default.
- W2069884888 hasConceptScore W2069884888C126322002 @default.
- W2069884888 hasConceptScore W2069884888C142724271 @default.
- W2069884888 hasConceptScore W2069884888C197934379 @default.
- W2069884888 hasConceptScore W2069884888C204787440 @default.
- W2069884888 hasConceptScore W2069884888C27081682 @default.
- W2069884888 hasConceptScore W2069884888C2776329913 @default.
- W2069884888 hasConceptScore W2069884888C2778163477 @default.
- W2069884888 hasConceptScore W2069884888C2778375690 @default.
- W2069884888 hasConceptScore W2069884888C2778715236 @default.
- W2069884888 hasConceptScore W2069884888C44249647 @default.
- W2069884888 hasConceptScore W2069884888C71924100 @default.
- W2069884888 hasConceptScore W2069884888C90924648 @default.
- W2069884888 hasIssue "4" @default.
- W2069884888 hasLocation W20698848881 @default.
- W2069884888 hasLocation W20698848882 @default.
- W2069884888 hasOpenAccess W2069884888 @default.
- W2069884888 hasPrimaryLocation W20698848881 @default.
- W2069884888 hasRelatedWork W137885780 @default.
- W2069884888 hasRelatedWork W1997070731 @default.
- W2069884888 hasRelatedWork W2003042623 @default.
- W2069884888 hasRelatedWork W2069884888 @default.
- W2069884888 hasRelatedWork W2145101709 @default.
- W2069884888 hasRelatedWork W2792428998 @default.
- W2069884888 hasRelatedWork W2884850942 @default.
- W2069884888 hasRelatedWork W2996750011 @default.
- W2069884888 hasRelatedWork W3023502736 @default.
- W2069884888 hasRelatedWork W4223500234 @default.
- W2069884888 hasVolume "16" @default.
- W2069884888 isParatext "false" @default.
- W2069884888 isRetracted "false" @default.
- W2069884888 magId "2069884888" @default.
- W2069884888 workType "article" @default.