FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069885909> ?p ?o ?g. }

• W2069885909 endingPage "e4122" @default.
• W2069885909 startingPage "e4122" @default.
• W2069885909 abstract "Background A replication defective influenza A vaccine virus (delNS1 virus) was developed. Its attenuation is due to potent stimulation of the innate immune system by the virus. Since the innate immune system can also target cancer cells, we reasoned that delNS1 virus induced immune-stimulation should also lead to the induction of innate cytotoxic effects towards cancer cells. Methodology/Principal Findings Peripheral blood mononuclear cells (PBMCs), isolated CD56+, CD3+, CD14+ and CD19+ subsets and different combinations of the above subsets were stimulated by delNS1, wild type (wt) virus or heat inactivated virus and co-cultured with tumor cell lines in the presence or absence of antibodies against the interferon system. Stimulation of PBMCs by the delNS1 virus effectively induced cytotoxicity against different cancer cell lines. Surprisingly, virus induced cytotoxicity was exerted by all major subtypes of PBMCs including CD56+, CD3+, CD14+ and CD19+ cells. Virus induced cytotoxicity in CD3+, CD14+ and CD19+ cells was dependent on virus replication, whereas virus induced cytotoxicity in CD56+ cells was only dependent on the binding of the virus. Virus induced cytotoxicity of isolated cell cultures of CD14+, CD19+ or CD56+ cells could be partially blocked by antibodies against type I and type II (IFN) interferon. In contrast, virus induced cytotoxicity in the complete PBMC preparation could not be inhibited by blocking type I or type II IFN, indicating a redundant system of activation in whole blood. Conclusions/Significance Our data suggest that apart from their well known specialized functions all main subsets of peripheral blood cells also initially exert a cytotoxic effect upon virus stimulation. This closely links the innate immune system to the adaptive immune response and renders delNS1 virus a potential therapeutic tool for viro-immunotherapy of cancer." @default.
• W2069885909 created "2016-06-24" @default.
• W2069885909 creator A5011480861 @default.
• W2069885909 creator A5022306082 @default.
• W2069885909 creator A5044559524 @default.
• W2069885909 creator A5060227600 @default.
• W2069885909 creator A5062963744 @default.
• W2069885909 creator A5083182869 @default.
• W2069885909 date "2009-01-06" @default.
• W2069885909 modified "2023-09-25" @default.
• W2069885909 title "Influenza A Virus Induces an Immediate Cytotoxic Activity in All Major Subsets of Peripheral Blood Mononuclear Cells" @default.
• W2069885909 cites W1512694957 @default.
• W2069885909 cites W1547450219 @default.
• W2069885909 cites W1548403485 @default.
• W2069885909 cites W1556867369 @default.
• W2069885909 cites W1800111497 @default.
• W2069885909 cites W1959947589 @default.
• W2069885909 cites W1972977765 @default.
• W2069885909 cites W1979386953 @default.
• W2069885909 cites W1994391392 @default.
• W2069885909 cites W1996735753 @default.
• W2069885909 cites W2009127910 @default.
• W2069885909 cites W2011017810 @default.
• W2069885909 cites W2011701477 @default.
• W2069885909 cites W2017309788 @default.
• W2069885909 cites W2029465014 @default.
• W2069885909 cites W2043175663 @default.
• W2069885909 cites W2043851305 @default.
• W2069885909 cites W2051690374 @default.
• W2069885909 cites W2058374284 @default.
• W2069885909 cites W2063395727 @default.
• W2069885909 cites W2067575233 @default.
• W2069885909 cites W2095812609 @default.
• W2069885909 cites W2109593713 @default.
• W2069885909 cites W2131960074 @default.
• W2069885909 cites W2145228084 @default.
• W2069885909 cites W2145356695 @default.
• W2069885909 cites W2150644383 @default.
• W2069885909 cites W2151778974 @default.
• W2069885909 cites W2161208630 @default.
• W2069885909 cites W2168853355 @default.
• W2069885909 doi "https://doi.org/10.1371/journal.pone.0004122" @default.
• W2069885909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2610492" @default.
• W2069885909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19125202" @default.
• W2069885909 hasPublicationYear "2009" @default.
• W2069885909 type Work @default.
• W2069885909 sameAs 2069885909 @default.
• W2069885909 citedByCount "12" @default.
• W2069885909 countsByYear W20698859092014 @default.
• W2069885909 countsByYear W20698859092015 @default.
• W2069885909 countsByYear W20698859092016 @default.
• W2069885909 countsByYear W20698859092020 @default.
• W2069885909 countsByYear W20698859092021 @default.
• W2069885909 countsByYear W20698859092023 @default.
• W2069885909 crossrefType "journal-article" @default.
• W2069885909 hasAuthorship W2069885909A5011480861 @default.
• W2069885909 hasAuthorship W2069885909A5022306082 @default.
• W2069885909 hasAuthorship W2069885909A5044559524 @default.
• W2069885909 hasAuthorship W2069885909A5060227600 @default.
• W2069885909 hasAuthorship W2069885909A5062963744 @default.
• W2069885909 hasAuthorship W2069885909A5083182869 @default.
• W2069885909 hasBestOaLocation W20698859091 @default.
• W2069885909 hasConcept C109316439 @default.
• W2069885909 hasConcept C136449434 @default.
• W2069885909 hasConcept C137061746 @default.
• W2069885909 hasConcept C154317977 @default.
• W2069885909 hasConcept C159047783 @default.
• W2069885909 hasConcept C159654299 @default.
• W2069885909 hasConcept C202751555 @default.
• W2069885909 hasConcept C203014093 @default.
• W2069885909 hasConcept C2522874641 @default.
• W2069885909 hasConcept C2776178377 @default.
• W2069885909 hasConcept C2778513237 @default.
• W2069885909 hasConcept C2778957590 @default.
• W2069885909 hasConcept C55493867 @default.
• W2069885909 hasConcept C86803240 @default.
• W2069885909 hasConcept C8891405 @default.
• W2069885909 hasConceptScore W2069885909C109316439 @default.
• W2069885909 hasConceptScore W2069885909C136449434 @default.
• W2069885909 hasConceptScore W2069885909C137061746 @default.
• W2069885909 hasConceptScore W2069885909C154317977 @default.
• W2069885909 hasConceptScore W2069885909C159047783 @default.
• W2069885909 hasConceptScore W2069885909C159654299 @default.
• W2069885909 hasConceptScore W2069885909C202751555 @default.
• W2069885909 hasConceptScore W2069885909C203014093 @default.
• W2069885909 hasConceptScore W2069885909C2522874641 @default.
• W2069885909 hasConceptScore W2069885909C2776178377 @default.
• W2069885909 hasConceptScore W2069885909C2778513237 @default.
• W2069885909 hasConceptScore W2069885909C2778957590 @default.
• W2069885909 hasConceptScore W2069885909C55493867 @default.
• W2069885909 hasConceptScore W2069885909C86803240 @default.
• W2069885909 hasConceptScore W2069885909C8891405 @default.
• W2069885909 hasIssue "1" @default.
• W2069885909 hasLocation W20698859091 @default.
• W2069885909 hasLocation W20698859092 @default.
• W2069885909 hasLocation W20698859093 @default.
• W2069885909 hasLocation W20698859094 @default.
• W2069885909 hasLocation W20698859095 @default.

• next