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• W2069887029 startingPage "14966" @default.
• W2069887029 abstract "Uropathogenic Escherichia coli invade bladder epithelial cells (BECs) by direct entry into specialized cAMP regulated exocytic compartments. Remarkably, a significant number of these intracellular bacteria are subsequently expelled in a nonlytic and piecemeal fashion by infected BECs. Here, we report that expulsion of intracellular E. coli by infected BECs is initiated by the pattern recognition receptor, Toll-like receptor (TLR)4, after activation by LPS. Also, we reveal that caveolin-1, Rab27b, PKA, and MyRIP are components of the exocytic compartment, and that they form a complex involved in the exocytosis of bacteria. This capacity of TLR4 to mediate the expulsion of intracellular bacteria from infected cells represents a previously unrecognized function for this innate immune receptor." @default.
• W2069887029 created "2016-06-24" @default.
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• W2069887029 date "2009-09-01" @default.
• W2069887029 modified "2023-09-28" @default.
• W2069887029 title "TLR4-mediated expulsion of bacteria from infected bladder epithelial cells" @default.
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• W2069887029 doi "https://doi.org/10.1073/pnas.0900527106" @default.
• W2069887029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2736405" @default.
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• W2069887029 hasPublicationYear "2009" @default.
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