Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069888931> ?p ?o ?g. }
- W2069888931 endingPage "220" @default.
- W2069888931 startingPage "211" @default.
- W2069888931 abstract "We report here the physicochemical and biological evaluation of a series of polymethacrylates with side groups of different pKa values, such as tertiary amines, pyridine groups, acid functions and imidazole groups as synthetic vectors for gene delivery. The ability of the different polymers to condense DNA was studied by ethidium bromide exclusion tests and agarose gel electrophoresis. The results show that all polymers are able to condense DNA. Both the molecular weight and the chemical composition of the polymers have an influence on the DNA condensation process. Furthermore, the biological properties of the polymer–DNA complexes were investigated, including their haemolytic activity, cytotoxicity and in vitro transfection efficiency. Complexes based on polymers containing only tertiary amines, have a transfection efficiency similar to that of poly(ethyleneimine) (PEI). Polymers containing pyridine groups have a reduced transfection efficiency compared to polymers containing tertiary amines. Introduction of imidazole groups or acid functions results in a loss of the transfection efficiency of the corresponding complexes with DNA. In general, the viability of cells incubated with complexes based on the polymethacrylates is higher than with PEI. Polymers with high transfection efficiency induce erythrocyte lysis." @default.
- W2069888931 created "2016-06-24" @default.
- W2069888931 creator A5000046652 @default.
- W2069888931 creator A5016711834 @default.
- W2069888931 creator A5027016284 @default.
- W2069888931 creator A5044612787 @default.
- W2069888931 creator A5075879769 @default.
- W2069888931 creator A5090528097 @default.
- W2069888931 creator A5091391650 @default.
- W2069888931 date "2003-03-01" @default.
- W2069888931 modified "2023-10-11" @default.
- W2069888931 title "Physicochemical and biological evaluation of cationic polymethacrylates as vectors for gene delivery" @default.
- W2069888931 cites W1576238436 @default.
- W2069888931 cites W1972545546 @default.
- W2069888931 cites W1993807849 @default.
- W2069888931 cites W1995551639 @default.
- W2069888931 cites W1999373563 @default.
- W2069888931 cites W2003017660 @default.
- W2069888931 cites W2007391969 @default.
- W2069888931 cites W2008911030 @default.
- W2069888931 cites W2013998409 @default.
- W2069888931 cites W2034655734 @default.
- W2069888931 cites W2036562414 @default.
- W2069888931 cites W2038984754 @default.
- W2069888931 cites W2044569715 @default.
- W2069888931 cites W2048928172 @default.
- W2069888931 cites W2053765988 @default.
- W2069888931 cites W2056538995 @default.
- W2069888931 cites W2058391956 @default.
- W2069888931 cites W2062820647 @default.
- W2069888931 cites W2071029835 @default.
- W2069888931 cites W2072054870 @default.
- W2069888931 cites W2078968390 @default.
- W2069888931 cites W2079791074 @default.
- W2069888931 cites W2080071319 @default.
- W2069888931 cites W2080648192 @default.
- W2069888931 cites W2083624809 @default.
- W2069888931 cites W2084132180 @default.
- W2069888931 cites W20847613 @default.
- W2069888931 cites W2088902418 @default.
- W2069888931 cites W2200831036 @default.
- W2069888931 cites W3023288964 @default.
- W2069888931 cites W4243583785 @default.
- W2069888931 cites W4250287065 @default.
- W2069888931 cites W4292328694 @default.
- W2069888931 cites W53334991 @default.
- W2069888931 doi "https://doi.org/10.1016/s0928-0987(02)00280-4" @default.
- W2069888931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12659932" @default.
- W2069888931 hasPublicationYear "2003" @default.
- W2069888931 type Work @default.
- W2069888931 sameAs 2069888931 @default.
- W2069888931 citedByCount "55" @default.
- W2069888931 countsByYear W20698889312013 @default.
- W2069888931 countsByYear W20698889312014 @default.
- W2069888931 countsByYear W20698889312015 @default.
- W2069888931 countsByYear W20698889312016 @default.
- W2069888931 countsByYear W20698889312017 @default.
- W2069888931 countsByYear W20698889312018 @default.
- W2069888931 countsByYear W20698889312020 @default.
- W2069888931 countsByYear W20698889312021 @default.
- W2069888931 countsByYear W20698889312022 @default.
- W2069888931 countsByYear W20698889312023 @default.
- W2069888931 crossrefType "journal-article" @default.
- W2069888931 hasAuthorship W2069888931A5000046652 @default.
- W2069888931 hasAuthorship W2069888931A5016711834 @default.
- W2069888931 hasAuthorship W2069888931A5027016284 @default.
- W2069888931 hasAuthorship W2069888931A5044612787 @default.
- W2069888931 hasAuthorship W2069888931A5075879769 @default.
- W2069888931 hasAuthorship W2069888931A5090528097 @default.
- W2069888931 hasAuthorship W2069888931A5091391650 @default.
- W2069888931 hasConcept C104317684 @default.
- W2069888931 hasConcept C115028873 @default.
- W2069888931 hasConcept C116084860 @default.
- W2069888931 hasConcept C135983454 @default.
- W2069888931 hasConcept C178790620 @default.
- W2069888931 hasConcept C183882617 @default.
- W2069888931 hasConcept C185592680 @default.
- W2069888931 hasConcept C21951064 @default.
- W2069888931 hasConcept C2776907736 @default.
- W2069888931 hasConcept C2778271344 @default.
- W2069888931 hasConcept C2778476535 @default.
- W2069888931 hasConcept C2778485729 @default.
- W2069888931 hasConcept C2780874372 @default.
- W2069888931 hasConcept C2909430059 @default.
- W2069888931 hasConcept C43617362 @default.
- W2069888931 hasConcept C521977710 @default.
- W2069888931 hasConcept C54009773 @default.
- W2069888931 hasConcept C552990157 @default.
- W2069888931 hasConcept C55493867 @default.
- W2069888931 hasConcept C57409179 @default.
- W2069888931 hasConceptScore W2069888931C104317684 @default.
- W2069888931 hasConceptScore W2069888931C115028873 @default.
- W2069888931 hasConceptScore W2069888931C116084860 @default.
- W2069888931 hasConceptScore W2069888931C135983454 @default.
- W2069888931 hasConceptScore W2069888931C178790620 @default.
- W2069888931 hasConceptScore W2069888931C183882617 @default.
- W2069888931 hasConceptScore W2069888931C185592680 @default.
- W2069888931 hasConceptScore W2069888931C21951064 @default.