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- W2069889664 abstract "The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis." @default.
- W2069889664 created "2016-06-24" @default.
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- W2069889664 date "2002-12-01" @default.
- W2069889664 modified "2023-10-12" @default.
- W2069889664 title "Keratinocyte Survival, Differentiation, and Death: Many Roads Lead to Mitogen-Activated Protein Kinase" @default.
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- W2069889664 doi "https://doi.org/10.1046/j.1523-1747.2002.19634.x" @default.
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