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- W2069891019 abstract "Abstract Infection of a host by pathogenic bacteria requires that the bacteria are able to bind to the target tissue to colonize and/or begin the process of invasion. This adhesion event involves specific interactions between receptors on the host tissue and external surface structures produced by the bacterial cell. Gram-positive bacteria utilize a special class of surface-anchored proteins for this purpose, while Gram-negative microorganisms use a more complex structure, called a pilus, to achieve the same end. In both cases, a highly conserved pathway is utilized to export, assemble and anchor these surface structures. As such, these pathways represent targets for antibiotic development. Compounds that prevent the assembly of bacterial surface proteins will cripple the ability of bacteria to interact with and colonize host tissue leading to rapid bacterial clearance from the body." @default.
- W2069891019 created "2016-06-24" @default.
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- W2069891019 date "1998-11-01" @default.
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- W2069891019 title "New targets for antibiotic development: biogenesis of surface adherence structures" @default.
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- W2069891019 doi "https://doi.org/10.1016/s1359-6446(98)01261-6" @default.
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