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- W2069892489 abstract "To attain fertilization the spermatozoon binds to the egg zona pellucida (ZP) via sperm receptor(s) and undergoes an acrosome reaction (AR). Several sperm receptors have been described in the literature; however, the identity of this receptor is not yet certain. In this study, we suggest that the α7 nicotinic acetylcholine receptor (α7nAChR) might be a sperm receptor activated by ZP to induce epidermal growth factor receptor (EGFR)-mediated AR. We found that isolated ZP or α7 agonists induced the AR in sperm from WT but not α7-null spermatozoa, and the induced AR was inhibited by α7 or EGFR antagonists. Moreover, α7-null sperm showed very little binding to the egg, and microfluidic affinity in vitro assay clearly showed that α7nAChR, as well as EGFR, interacted with ZP3. Induction of EGFR activation and the AR by an α7 agonist was inhibited by a Src family kinase (SFK) inhibitor. In conclusion we suggest that activation of α7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction." @default.
- W2069892489 created "2016-06-24" @default.
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- W2069892489 creator A5046615745 @default.
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- W2069892489 date "2012-06-01" @default.
- W2069892489 modified "2023-10-01" @default.
- W2069892489 title "Sperm Epidermal Growth Factor Receptor (EGFR) Mediates α7 Acetylcholine Receptor (AChR) Activation to Promote Fertilization" @default.
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- W2069892489 cites W1673863031 @default.
- W2069892489 cites W1739486953 @default.
- W2069892489 cites W1922120593 @default.
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- W2069892489 cites W1992913621 @default.
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- W2069892489 cites W1995242599 @default.
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- W2069892489 cites W1997739246 @default.
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- W2069892489 cites W2015313977 @default.
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- W2069892489 cites W2050578621 @default.
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- W2069892489 cites W2055304027 @default.
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- W2069892489 cites W2065278977 @default.
- W2069892489 cites W2068350567 @default.
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- W2069892489 cites W2088303320 @default.
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- W2069892489 cites W2122706875 @default.
- W2069892489 cites W2127489545 @default.
- W2069892489 cites W2129434760 @default.
- W2069892489 cites W2144162370 @default.
- W2069892489 cites W2148129138 @default.
- W2069892489 cites W2154320021 @default.
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- W2069892489 cites W2161605623 @default.
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- W2069892489 cites W2168448850 @default.
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- W2069892489 doi "https://doi.org/10.1074/jbc.m111.292292" @default.
- W2069892489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3381193" @default.
- W2069892489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22577141" @default.
- W2069892489 hasPublicationYear "2012" @default.
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