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• W2069892944 abstract "Abstract Six DNA-negative, temperature-sensitive ( ts ) mutants ( ts B, ts D, ts E, ts K, ts S, and ts T) of herpes simplex virus type 1, which fall into four complementation groups, have been characterized by analyses of the nuclear and cytoplasmic transcripts synthesized in cells infected at the restrictive temperature. Transcripts were hybridized to blot strips containing the separated fragments of virus DNA generated by digestion with restriction endonucleases Hin d III, Hpa I, or Bam H1. The hybridization patterns thus obtained have been compared with the patterns given by RNA isolated from cells infected with wild-type virus and labeled at early and late times postinfection (before and after viral DNA replication), or in the continuous presence of inhibitors of DNA or protein synthesis (Clements, J. B., Watson, R. J., and Wilkie, N. M. (1977). Cell 12 , 275–285). Of these mutants, ts K is the most restricted in transcription and gives a pattern of hybridization similar to that observed with immediate-early RNA (transcribed in the absence of protein synthesis). Two mutants ( ts D and ts T), which lie in a different complementation group to ts K, also give restricted hybridization patterns but express additional regions of the genome as compared with ts K RNA. Inasmuch as these three mutants fall into two complementation groups, these experiments suggest that at least two viral products are required to progress from the immediate-early to the early stage of transcription. The hybridization patterns obtained with the other early mutants examined here ( ts B, ts E, and ts S) are, in contrast, much less restricted, and resemble the early, rather than late pattern. Downshift of ts K-infected cells from the nonpermissive to the permissive temperature, both in the presence and absence of further protein synthesis, results in the transcription of regions which map throughout the viral genome. These experiments suggest, therefore, that the polypeptides which are required for the switch-on of these additional transcripts accumulate in ts K-infected cells under restrictive conditions." @default.
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• W2069892944 date "1978-12-01" @default.
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• W2069892944 title "Characterization of transcription-deficient temperature-sensitive mutants of herpes simplex virus type 1" @default.
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• W2069892944 doi "https://doi.org/10.1016/0042-6822(78)90384-7" @default.
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