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• W2069895730 abstract "CD4+CD25high regulatory T cells (Treg) have the potent ability to suppress host immune responses, thus preventing autoimmune diseases. However, increased Treg frequencies have also been found in cancer patients implicating their involvement in tumor escape from immunological control. We investigated the frequency, functional effects and gene expression pattern of Treg in patients with renal cell carcinoma (RCC). Therefore, Treg were isolated from the peripheral blood of 11 treatment-naïve RCC patients and 11 healthy donors applying a magnetic cell separation system. Frequency, purity after isolation and function were evaluated using FACS and suppression assays, respectively. Gene expression patterns were compared applying a self-developed customized oligonucleotide microarray and by quantitative RT-PCR. Treg frequencies were significantly increased in RCC patients; suppression assays proved that the isolated CD4+CD25high cells had the functional characteristics of Treg cells. Comparing gene expression profiles between Treg of RCC patients and healthy controls revealed significant differences in the expression levels of 49 genes. Gene ontology identified an association of significantly up-/downregulated genes to six functional classes, particularly genes involved in apoptosis control such as LGALS1, LGALS3, BAX, IL7R and TNFRSF25. In RCC patients, frequencies of functionally active Treg cells were elevated; the Treg gene expression pattern differed significantly between patients and controls. As several anti-apoptotic genes were upregulated and pro-apoptotic genes were downregulated in RCC patients, we conclude that Treg cells derived from RCC patients might be less responsive to apoptotic stimuli, possibly promoting their accumulation in tumor patients." @default.
• W2069895730 created "2016-06-24" @default.
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• W2069895730 date "2009-01-01" @default.
• W2069895730 modified "2023-09-25" @default.
• W2069895730 title "Frequency and Gene Expression Profile of Regulatory T Cells in Renal Cell Carcinoma" @default.
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• W2069895730 doi "https://doi.org/10.1159/000228909" @default.
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