Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069896544> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2069896544 endingPage "430" @default.
- W2069896544 startingPage "425" @default.
- W2069896544 abstract "Abnormalities involving chromosome 13 have been reported as the only cytogenetic change in B-cell chronic lymphocytic leukemia (BCLL). Deletions are the most common cytogenetic abnormality and always involve 13q14, but when translocations are seen, the consistent breakpoint is always in 13q14. It is now established that deletions, distal to the RB1 gene in 13q14, are invariably associated with these translocations. We have recently described the smallest such deletion from a series of rearrangements from these tumors isolated in somatic cell hybrids, which spans approximately 1 Mb. In this report, we present the results of a series of a chromosome walking experiments using YACs and have been able to span this small deletion, which must contain the gene that is frequently deleted in BCLL. Four probes from 13q14 (RB1-mgg15-D13S25-D13S31) were used to isolate corresponding YACs for each of the markers. The chromosomal location of these YACs was verified using FISH, which also demonstrated their nonchimeric nature. Vectorette end rescue was then used to demonstrate the overlap of the YACs and to isolate new clones to complete the contig. The extremes of the contig were shown to cross the chromosome 13 translocation breakpoints isolated in somatic cell hybrids that carry the derivatives of chromosome 13 involved in the smallest BCLL deletion. This YAC contig covers the entire deletion and will prove a valuable resource to begin isolating genes from this region. In addition, we have isolated YACs corresponding to the RB1 locus, which extends the contig over a 3.8-cM distance on the chromosome." @default.
- W2069896544 created "2016-06-24" @default.
- W2069896544 creator A5062917844 @default.
- W2069896544 creator A5073029119 @default.
- W2069896544 creator A5073485583 @default.
- W2069896544 creator A5079808476 @default.
- W2069896544 creator A5084822331 @default.
- W2069896544 date "1995-12-01" @default.
- W2069896544 modified "2023-09-26" @default.
- W2069896544 title "A Yeast Artificial Chromosome Contig That Spans the RB1-D13S31 Interval on Human Chromosome 13 and Encompasses the Frequently Deleted Region in B-cell Chronic Lymphocytic Leukemia" @default.
- W2069896544 doi "https://doi.org/10.1006/geno.1995.1260" @default.
- W2069896544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8825626" @default.
- W2069896544 hasPublicationYear "1995" @default.
- W2069896544 type Work @default.
- W2069896544 sameAs 2069896544 @default.
- W2069896544 citedByCount "20" @default.
- W2069896544 crossrefType "journal-article" @default.
- W2069896544 hasAuthorship W2069896544A5062917844 @default.
- W2069896544 hasAuthorship W2069896544A5073029119 @default.
- W2069896544 hasAuthorship W2069896544A5073485583 @default.
- W2069896544 hasAuthorship W2069896544A5079808476 @default.
- W2069896544 hasAuthorship W2069896544A5084822331 @default.
- W2069896544 hasConcept C104317684 @default.
- W2069896544 hasConcept C122735190 @default.
- W2069896544 hasConcept C138626823 @default.
- W2069896544 hasConcept C141231307 @default.
- W2069896544 hasConcept C143191323 @default.
- W2069896544 hasConcept C206936463 @default.
- W2069896544 hasConcept C30481170 @default.
- W2069896544 hasConcept C54355233 @default.
- W2069896544 hasConcept C59582021 @default.
- W2069896544 hasConcept C6970260 @default.
- W2069896544 hasConcept C84597430 @default.
- W2069896544 hasConcept C86803240 @default.
- W2069896544 hasConceptScore W2069896544C104317684 @default.
- W2069896544 hasConceptScore W2069896544C122735190 @default.
- W2069896544 hasConceptScore W2069896544C138626823 @default.
- W2069896544 hasConceptScore W2069896544C141231307 @default.
- W2069896544 hasConceptScore W2069896544C143191323 @default.
- W2069896544 hasConceptScore W2069896544C206936463 @default.
- W2069896544 hasConceptScore W2069896544C30481170 @default.
- W2069896544 hasConceptScore W2069896544C54355233 @default.
- W2069896544 hasConceptScore W2069896544C59582021 @default.
- W2069896544 hasConceptScore W2069896544C6970260 @default.
- W2069896544 hasConceptScore W2069896544C84597430 @default.
- W2069896544 hasConceptScore W2069896544C86803240 @default.
- W2069896544 hasIssue "3" @default.
- W2069896544 hasLocation W20698965441 @default.
- W2069896544 hasLocation W20698965442 @default.
- W2069896544 hasOpenAccess W2069896544 @default.
- W2069896544 hasPrimaryLocation W20698965441 @default.
- W2069896544 hasRelatedWork W1966910063 @default.
- W2069896544 hasRelatedWork W1979492437 @default.
- W2069896544 hasRelatedWork W2009760047 @default.
- W2069896544 hasRelatedWork W2029953753 @default.
- W2069896544 hasRelatedWork W2045748275 @default.
- W2069896544 hasRelatedWork W2048554341 @default.
- W2069896544 hasRelatedWork W2145799335 @default.
- W2069896544 hasRelatedWork W2147212144 @default.
- W2069896544 hasRelatedWork W2151959393 @default.
- W2069896544 hasRelatedWork W2254306972 @default.
- W2069896544 hasVolume "30" @default.
- W2069896544 isParatext "false" @default.
- W2069896544 isRetracted "false" @default.
- W2069896544 magId "2069896544" @default.
- W2069896544 workType "article" @default.