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- W2069896549 abstract "An isotopic dilution procedure using specific prostaglandin E2 (PGE2) brain receptors was utilized to determine the changes in brain PGE2 levels subsequent to drug exposure. Delta-1-tetrahydrocannabinol (Δ1-THC) stimulated PGE2 synthesis resulting in increased brain concentrations when compared with vehicle treated rats and mice. Indomethacin markedly inhibited the Δ1-THC elevated rise in PGE2 levels presumably by inhibition of prostaglandin synthetase. The Δ1-THC-induced increase in PGE2 brain levels was also suppressed by i.v. administered rabbit PGE2-antiserum. This suggests that one of the sites of Δ1-THC action is extracerebral and from here a portion of the released prostaglandins are transported to the brain. These results add further support to previous data that Δ1-THC given orally results in an increase in brain PGE2 levels." @default.
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- W2069896549 date "1991-07-01" @default.
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- W2069896549 title "Elevation of brain prostaglandin E2 levels in rodents by Δ1-tetrahydrocannabinol" @default.
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- W2069896549 doi "https://doi.org/10.1016/0952-3278(91)90167-4" @default.
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