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• W2069897021 abstract "Abstract The concentration of albumin in the serum of the pig increases rapidly after birth. Synthesis of porcine serum albumin (PSA) was studied in perinatal piglets by means of immunological precipitation of PSA by a rabbit antiserum demonstrated to be specific for PSA. Radioactive leucine ( 14 C or 3 H) incorporation into PSA in vivo , expressed as a percentage of the incorporation into total serum protein, was 10 times as great in 10-day-old animals as in prenatal animals, a sharp increase occurring at or near the time of birth. Net synthesis of PSA by liver slices was 5–10 times greater in slices from 10-day-old and 14-day-old animals than in slices from newborn, unsuckled animals. Net synthesis of PSA was not detected in liver slices from a prenatal animal. Incorporation of radioactive leucine into PSA by liver slices was assayed under conditions in which incorporation into both PSA and total protein was proportional to the wet weight of the slice and to the radioactivity added. Incorporation of radioactivity into PSA was 2- to 15-fold greater in slices taken from animals 4–14 days of age than in slices from newborn animals. The specific activity of PSA in liver slices from the older animals was higher than in liver slices from newborns, despite the much higher concentrations of PSA in the livers of the older animals. When incorporation of radioactivity into PSA was expressed as a percentage of the total radioactivity in protein, the increase in labeling of PSA was 5- to 10-fold in the same age interval. Again, the sharpest increase occurs at or near birth. These results indicate that the rate of synthesis of albumin increases abruptly in the liver of the postnatal piglet and that it increases out of proportion to the rate of synthesis of the bulk of liver proteins. This increase in the rate of synthesis of albumin is thus a selective alteration of patterns of protein synthesis in the liver. It is sufficient to account for the rising concentration of albumin in the serum of the postnatal piglet." @default.
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• W2069897021 date "1969-08-01" @default.
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• W2069897021 title "In vivo and in vitro studies on the synthesis of albumin by perinatal pigs" @default.
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• W2069897021 doi "https://doi.org/10.1016/0012-1606(69)90009-8" @default.
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