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• W2069898892 abstract "Authors' reply Sir—Current policy decisions on use and sourcing of blood and blood products in the UK and elsewhere have necessarily been taken in the absence of any direct data on PrPSc concentrations, infectivity, or both, in blood in vCJD. Muttuswamy Sivakumaran correctly identifies the cell fraction from vCJD peripheral whole blood prepared by the method as we described as monocytes and lymphocytes. Although monocytes and lymphocytes are major components of buffy coat, we agree that our description of this fraction as a buffy coat was semantically incorrect and, accordingly, we agree with Sivakumaran that our results on the potential concentrations of PrPSc in vCJD blood are applicable only to peripheral blood lymphocytes. We used Accuspin System Histopaque-1077 tubes because we placed a high priority on examining lymphocytes from vCJD blood. The demonstration of the involvement of lymphoreticular tissue in the peripheral pathogenesis of vCJD,1Hill AF Zeidler M Ironside J Collinge J Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy.Lancet. 1997; 349: 99-100Summary Full Text Full Text PDF PubMed Scopus (392) Google Scholar together with evidence for a crucial role for B-lymphocytes in prion neuroinvasion in rodents,2Klein MA Frigg R Flechsig E et al.A crucial role for B cells in neuroinvasive scrapie.Nature. 1997; 390: 687-690Crossref PubMed Scopus (445) Google Scholar led the UK Spongiform Encephalopathy Advisory Committee, in 1998, to deem that, if any infectious agent were present in human blood, it would most probably be in lymphocytes.3UK Department of HealthGovernment accepts advice on leucodepletion from Spongiform Encephalopathy Advisory Committee.UK Department of Health press release. 1998; : 98/295Google Scholar Although we reported the analysis of the lymphocyte fraction of blood from only one vCJD patient, our failure to detect PrPSc suggests that if any is present it is at concentrations far lower than those reported in secondary lymphoid organs (tonsil, spleen, and lymph node). Work on more detailed analysis of cellular fractions from vCJD blood and on higher sensitivity diagnostic methods are now being done in our laboratory. Distribution of infectivity in variant Creutzfeldt-Jakob diseaseThe development of a highly sensitive immunoblotting assay to detect PrPSc in various tissues of patients with variant Creutzfeldt-Jakob disease (vCJD), described by J Wadsworth and colleagues (July 21, p 171),1 is an important step forward in the bid to develop a rapid and sensitive diagnostic test. However, because of a flaw in their methods for preparation of blood cells used in the experiments, their conclusion about the infectivity of peripheral blood buffy coat cells is inaccurate. Full-Text PDF" @default.
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• W2069898892 title "Distribution of infectivity in variant Creutzfeldt-Jakob disease" @default.
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• W2069898892 doi "https://doi.org/10.1016/s0140-6736(02)07865-0" @default.
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