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W2069901076 abstract "A series of novel 2-alkoxy, 2-thioalkoxy and 2-amino-3-(4-methylsulfonyl)phenylpyridines has been synthesized and shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. Structure-activity relationship studies have demonstrated that central pyridine ring substituents play an important role in the COX-2 potency, selectivity vs the COX-1 enzyme, and oral activity." @default.
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W2069901076 date "1999-06-01" @default.
W2069901076 modified "2023-10-03" @default.
W2069901076 title "2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors" @default.
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W2069901076 doi "https://doi.org/10.1016/s0960-894x(99)00264-4" @default.
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