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- W2069915846 abstract "Increasing oxygen demand by muscle contraction and reducing oxygen delivery by acute hypoxia are both known to accelerate the rate of muscle glucose transport, a process mediated by the rapid recruitment of intracellular GLUT4 protein to plasma membranes. In a chronic state, regular exercise training was found to elevate muscle GLUT4 protein expression, which in turn increases muscle glycogen storage and improves glucose tolerance. In order to compare differences between exercise and hypoxia adaptation on glucose metabolism, we studied the independent and interactive effects of exercise training and prolonged intermittent hypoxia on glucose tolerance, muscle GLUT4 protein expression, and glycogen storage. PURPOSE: Try to compare the difference between chronic effect of intermittent hypoxia and endurance training on the glucose tolerance and GLUT4 protein expression in rat skeletal muscle. METHODS: Thirty-two Sprague-Dawley rats were weight-matched and assigned to 1 of the following 4 groups: control, endurance training, hypoxia, or hypoxia followed by endurance training. Hypoxic treatment consisted of breathing 14% O for 12 h/d under normobaric conditions, and the training protocol consisted of making animals swim 2 times for 3 h/d. At the end of the third week, an oral glucose tolerance test (OGTT) was performed 16 h after treatments. At the end of the fourth week, GLUT4 protein, mRNA, and glycogen storage in skeletal muscle were determined. RESULTS: Endurance training significantly improved OGTT results. Glycogen content and GLUT4 protein expression in the plantaris and red gastrocnemius, but not in the soleus or white gastrocnemius muscles, were also elevated. Chronic intermittent hypoxia also improved OGTT results, but did not alter GLUT4 protein expression. Additionally, hypoxia followed by exercise training produced significant increases in GLUT4 protein and mRNA in a greater number of muscles compared to endurance training alone. Both exercise training and hypoxia significantly reduced body mass, and an additive effect of both treatments was found. CONCLUSION: Chronic intermittent hypoxia improved glucose tolerance in the absence of increased GLUT4 protein expression. This treatment facilitated the exercise training effect on muscle GLUT4 expression and glycogen storage. These new findings open the possibility of utilizing intermittent hypoxia, with or without exercise training, for prevention and clinical treatment of type 2 diabetes or insulin resistance." @default.
- W2069915846 created "2016-06-24" @default.
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- W2069915846 date "2006-05-01" @default.
- W2069915846 modified "2023-09-27" @default.
- W2069915846 title "Hypoxia Facilitates Exercise Training Effect on Glucose Tolerance and Insulin Sensitivity in Rats" @default.
- W2069915846 doi "https://doi.org/10.1249/00005768-200605001-01715" @default.
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