FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069916227> ?p ?o ?g. }

• W2069916227 endingPage "461" @default.
• W2069916227 startingPage "451" @default.
• W2069916227 abstract "Background The reason for the delay in onset of the electrophysiological effects and antiarrhythmic efficacy of amiodarone is not clear. The relation between the development of the electrophysiological effects of amiodarone and its myocardial concentration is unknown. We therefore examined the time course of development of electrophysiological effects during intracoronary infusion of amiodarone and related these changes to myocardial concentrations. Methods and Results Amiodarone (0.139 mg/min) or normal saline was infused for 10 hours into the proximal left anterior descending coronary artery of 24 open-chest dogs. Nineteen animals received intracoronary amiodarone and 5 received normal saline (control group). Ten of the 19 that received amiodarone underwent electrophysiological study (amio-EPS group). Sixteen of the 19, including 7 from the amio-EPS group, underwent pharmacological study (PS group). In the amio-EPS group during pacing at a cycle length of 300 ms, changes in conduction velocities in drug-exposed myocardium referenced to nonexposed myocardium at 1 hour of infusion were −3.7% in the longitudinal direction ( P =NS) and −7.2% in the transverse direction ( P <.05); at 3 hours, −12.9% ( P <.05) and −9.1% ( P <.05); and at 9 hours, −32.9% ( P <.02) and −31.7% ( P <.01). These changes were dependent on amiodarone concentration ( R 2 =.83). There was also an obvious rate-dependent effect that was more pronounced for transverse conduction velocities. This effect was also dependent on amiodarone concentration. In the PS group, amiodarone levels in the drug-exposed myocardium increased from a mean of 5.95 μg/g at 15 minutes of infusion to 188.88 μg/g at the 10th hour. This increase was time dependent ( R 2 =.91). In the nonexposed myocardium, amiodarone levels were always low and increased minimally over time from a mean of 2.68 to 14.45 μg/g. This increase was also time dependent ( R 2 =.97). Conclusions Selective intracoronary amiodarone infusion resulted in selective drug accumulation and concomitant time-dependent reduction of myocardial conduction velocity. There was a significant correlation between the extent of reduction of conduction velocity and myocardial amiodarone concentration but not coronary arterial or systemic concentration. Repolarization was not significantly altered." @default.
• W2069916227 created "2016-06-24" @default.
• W2069916227 creator A5004578083 @default.
• W2069916227 creator A5038222647 @default.
• W2069916227 date "1995-01-15" @default.
• W2069916227 modified "2023-10-11" @default.
• W2069916227 title "Pharmacokinetics and Regional Electrophysiological Effects of Intracoronary Amiodarone Administration" @default.
• W2069916227 cites W1965695368 @default.
• W2069916227 cites W1967064051 @default.
• W2069916227 cites W1975544435 @default.
• W2069916227 cites W1976169005 @default.
• W2069916227 cites W1982762147 @default.
• W2069916227 cites W1983541140 @default.
• W2069916227 cites W1986644075 @default.
• W2069916227 cites W1988631676 @default.
• W2069916227 cites W1995936558 @default.
• W2069916227 cites W2002965836 @default.
• W2069916227 cites W2005631766 @default.
• W2069916227 cites W2015792350 @default.
• W2069916227 cites W2017403458 @default.
• W2069916227 cites W2018472105 @default.
• W2069916227 cites W2022961147 @default.
• W2069916227 cites W2028900561 @default.
• W2069916227 cites W2030057176 @default.
• W2069916227 cites W2031479016 @default.
• W2069916227 cites W2036140038 @default.
• W2069916227 cites W2038773418 @default.
• W2069916227 cites W2043600848 @default.
• W2069916227 cites W2045010449 @default.
• W2069916227 cites W2049476120 @default.
• W2069916227 cites W2054352050 @default.
• W2069916227 cites W2074852747 @default.
• W2069916227 cites W2079017227 @default.
• W2069916227 cites W2088132763 @default.
• W2069916227 cites W2089724698 @default.
• W2069916227 cites W2091262670 @default.
• W2069916227 cites W2131312586 @default.
• W2069916227 cites W2150796618 @default.
• W2069916227 cites W2165142491 @default.
• W2069916227 cites W2196763083 @default.
• W2069916227 cites W4213205077 @default.
• W2069916227 cites W4233704600 @default.
• W2069916227 doi "https://doi.org/10.1161/01.cir.91.2.451" @default.
• W2069916227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7805250" @default.
• W2069916227 hasPublicationYear "1995" @default.
• W2069916227 type Work @default.
• W2069916227 sameAs 2069916227 @default.
• W2069916227 citedByCount "24" @default.
• W2069916227 countsByYear W20699162272014 @default.
• W2069916227 countsByYear W20699162272015 @default.
• W2069916227 countsByYear W20699162272017 @default.
• W2069916227 countsByYear W20699162272023 @default.
• W2069916227 crossrefType "journal-article" @default.
• W2069916227 hasAuthorship W2069916227A5004578083 @default.
• W2069916227 hasAuthorship W2069916227A5038222647 @default.
• W2069916227 hasConcept C126322002 @default.
• W2069916227 hasConcept C164705383 @default.
• W2069916227 hasConcept C185263204 @default.
• W2069916227 hasConcept C2776894844 @default.
• W2069916227 hasConcept C2777397205 @default.
• W2069916227 hasConcept C2778094803 @default.
• W2069916227 hasConcept C2778131192 @default.
• W2069916227 hasConcept C2779161974 @default.
• W2069916227 hasConcept C2780074459 @default.
• W2069916227 hasConcept C42219234 @default.
• W2069916227 hasConcept C71924100 @default.
• W2069916227 hasConceptScore W2069916227C126322002 @default.
• W2069916227 hasConceptScore W2069916227C164705383 @default.
• W2069916227 hasConceptScore W2069916227C185263204 @default.
• W2069916227 hasConceptScore W2069916227C2776894844 @default.
• W2069916227 hasConceptScore W2069916227C2777397205 @default.
• W2069916227 hasConceptScore W2069916227C2778094803 @default.
• W2069916227 hasConceptScore W2069916227C2778131192 @default.
• W2069916227 hasConceptScore W2069916227C2779161974 @default.
• W2069916227 hasConceptScore W2069916227C2780074459 @default.
• W2069916227 hasConceptScore W2069916227C42219234 @default.
• W2069916227 hasConceptScore W2069916227C71924100 @default.
• W2069916227 hasIssue "2" @default.
• W2069916227 hasLocation W20699162271 @default.
• W2069916227 hasLocation W20699162272 @default.
• W2069916227 hasOpenAccess W2069916227 @default.
• W2069916227 hasPrimaryLocation W20699162271 @default.
• W2069916227 hasRelatedWork W10180507 @default.
• W2069916227 hasRelatedWork W1974976565 @default.
• W2069916227 hasRelatedWork W1994160082 @default.
• W2069916227 hasRelatedWork W2010658339 @default.
• W2069916227 hasRelatedWork W2083470764 @default.
• W2069916227 hasRelatedWork W2088339331 @default.
• W2069916227 hasRelatedWork W2117178763 @default.
• W2069916227 hasRelatedWork W2241528882 @default.
• W2069916227 hasRelatedWork W2790054207 @default.
• W2069916227 hasRelatedWork W4240290406 @default.
• W2069916227 hasVolume "91" @default.
• W2069916227 isParatext "false" @default.
• W2069916227 isRetracted "false" @default.
• W2069916227 magId "2069916227" @default.
• W2069916227 workType "article" @default.