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- W2069921921 abstract "Magnesium has an important role in excitation-contraction coupling in smooth and skeletal muscle, through mechanisms that are not yet fully understood. Magnesium interacts with calcium activity, possibly by inducing calcium-channel blockade. 1 Levine BS Coburn JW Magnesium, the mimic/antagonist of calcium. N Engl J Med. 1984; 310: 1253-1255 Crossref PubMed Scopus (167) Google Scholar In the airway, calcium is mobilised for smooth-muscle contraction either from extracellular stores via voltage-sensitive calcium channels or from intracellular stores via receptor-operated channels. Bronchoconstrictors activate one or both types of calcium channel. Calcium-channel blockers (nifedipine, diltiazem, and verapamil) are thought to act by blocking voltage-sensitive channels in airway smooth muscle, and to offer variable protection against some bronchoconstrictive stimuli (eg, histamine, exercise, allergens) in asthmatic patients. 2 Russi EW Ahmed T Calcium and calcium antagonists in airway disease: a review. Chest. 1984; 86: 475-482 Summary Full Text Full Text PDF PubMed Scopus (39) Google Scholar Magnesium can block or compete with Ca2+ at voltage-sensitive or receptor-operated channels. Studies in vitro show the inhibitory effect of magnesium on contraction in bronchial smooth muscle, and on the release of acetylcholine from cholinergic nerve terminals and of histamine from mast cells. 3 Mathew R Altura BM Magnesium and the lungs. Magnesium. 1988; 7: 173-187 PubMed Google Scholar Use of isotonic nebulised magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomised placebo-controlled trialUse of isotonic magnesium as an adjuvant to nebulised salbutamol results in an enhanced bronchodilator response in treatment of severe asthma. Full-Text PDF" @default.
- W2069921921 created "2016-06-24" @default.
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- W2069921921 date "2003-06-01" @default.
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- W2069921921 title "Nebulised magnesium in asthma: the right solution for an old remedy?" @default.
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- W2069921921 doi "https://doi.org/10.1016/s0140-6736(03)13727-0" @default.
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