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- W2069932403 abstract "<i>Background:</i> Hepatocyte growth factor (HGF) has the capacity to selectively direct thalamocortical projections into an intermediate target, the pallidum, and eventually to their final cortical destination. HGF may have a role in the mediation of anxiety. Very little is known about other central behavioral effects of HGF. <i>Objective:</i> Our aim was to determine what effect HGF has on anxiety in rats. <i>Methods:</i> HGF was infused at a constant rate into cerebral lateral ventricles and its effect on anxiety in rats was monitored. <i>Results:</i> In the elevated plus maze test and the black and white box test, HGF administration caused all indicators of anxiety to increase. No significant effect on general locomotor activity was seen. <i>Conclusion:</i> HGF infusion into the brain produces an anxiolytic effect." @default.
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- W2069932403 date "2005-01-01" @default.
- W2069932403 modified "2023-09-27" @default.
- W2069932403 title "Anxiolytic Effect of Hepatocyte Growth Factor Infused into Rat Brain" @default.
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- W2069932403 doi "https://doi.org/10.1159/000082853" @default.
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