FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069933440> ?p ?o ?g. }

• W2069933440 endingPage "102" @default.
• W2069933440 startingPage "96" @default.
• W2069933440 abstract "A series of 3-substituted [1,2,4]triazino[4,3-c]benzimidazoles V were prepared and tested at the central benzodiazepine receptor (BzR). These compounds were designed as rigid analogues of the previously described N-benzylindolylglyoxylylamide derivatives IV. The title compounds V showed an affinity which depended directly on the presence of the N(10)-H group and an aromatic ring at position 3. Some of them elicited a 2- or 3-fold higher affinity with respect to that of the indolylglyoxylylamide derivatives IV (R = H). The GABA ratio and [(35)S]-tert-butylcyclophosphorothionate binding data revealed an efficacy profile of partial inverse agonists/antagonists for compounds 1c,e,f,j,k, and of a partial agonist for 2c. This last compound proved to be effective in antagonizing pentylenetetrazole-induced seizures in mice. Attempts were made to interpret the structure-affinity relationships of compounds V in the light of possible tautomeric equilibria involving the ligands." @default.
• W2069933440 created "2016-06-24" @default.
• W2069933440 creator A5002153460 @default.
• W2069933440 creator A5010550259 @default.
• W2069933440 creator A5021153019 @default.
• W2069933440 creator A5026476213 @default.
• W2069933440 creator A5040940946 @default.
• W2069933440 creator A5051863495 @default.
• W2069933440 creator A5067808979 @default.
• W2069933440 creator A5076211653 @default.
• W2069933440 creator A5079136016 @default.
• W2069933440 creator A5089468313 @default.
• W2069933440 date "1999-12-10" @default.
• W2069933440 modified "2023-10-17" @default.
• W2069933440 title "3-Aryl-[1,2,4]triazino[4,3-<i>a</i>]benzimidazol-4(10<i>H</i>)-ones: Tricyclic Heteroaromatic Derivatives as a New Class of Benzodiazepine Receptor Ligands" @default.
• W2069933440 cites W1775749144 @default.
• W2069933440 cites W1979541512 @default.
• W2069933440 cites W1980661175 @default.
• W2069933440 cites W1981301927 @default.
• W2069933440 cites W1984828871 @default.
• W2069933440 cites W1987271870 @default.
• W2069933440 cites W1995735600 @default.
• W2069933440 cites W1998926788 @default.
• W2069933440 cites W2004900115 @default.
• W2069933440 cites W2007618885 @default.
• W2069933440 cites W2008962691 @default.
• W2069933440 cites W2039267782 @default.
• W2069933440 cites W2071659156 @default.
• W2069933440 cites W2078681603 @default.
• W2069933440 cites W2095575967 @default.
• W2069933440 cites W2146930103 @default.
• W2069933440 cites W2176076159 @default.
• W2069933440 cites W2949632600 @default.
• W2069933440 cites W2949776953 @default.
• W2069933440 cites W2949888073 @default.
• W2069933440 cites W2950601179 @default.
• W2069933440 cites W2951425679 @default.
• W2069933440 doi "https://doi.org/10.1021/jm991131h" @default.
• W2069933440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10633040" @default.
• W2069933440 hasPublicationYear "1999" @default.
• W2069933440 type Work @default.
• W2069933440 sameAs 2069933440 @default.
• W2069933440 citedByCount "21" @default.
• W2069933440 countsByYear W20699334402012 @default.
• W2069933440 countsByYear W20699334402013 @default.
• W2069933440 countsByYear W20699334402014 @default.
• W2069933440 countsByYear W20699334402016 @default.
• W2069933440 countsByYear W20699334402018 @default.
• W2069933440 countsByYear W20699334402020 @default.
• W2069933440 crossrefType "journal-article" @default.
• W2069933440 hasAuthorship W2069933440A5002153460 @default.
• W2069933440 hasAuthorship W2069933440A5010550259 @default.
• W2069933440 hasAuthorship W2069933440A5021153019 @default.
• W2069933440 hasAuthorship W2069933440A5026476213 @default.
• W2069933440 hasAuthorship W2069933440A5040940946 @default.
• W2069933440 hasAuthorship W2069933440A5051863495 @default.
• W2069933440 hasAuthorship W2069933440A5067808979 @default.
• W2069933440 hasAuthorship W2069933440A5076211653 @default.
• W2069933440 hasAuthorship W2069933440A5079136016 @default.
• W2069933440 hasAuthorship W2069933440A5089468313 @default.
• W2069933440 hasConcept C111233374 @default.
• W2069933440 hasConcept C114373084 @default.
• W2069933440 hasConcept C155647269 @default.
• W2069933440 hasConcept C168258287 @default.
• W2069933440 hasConcept C170493617 @default.
• W2069933440 hasConcept C178790620 @default.
• W2069933440 hasConcept C185592680 @default.
• W2069933440 hasConcept C202751555 @default.
• W2069933440 hasConcept C2778173252 @default.
• W2069933440 hasConcept C2778938600 @default.
• W2069933440 hasConcept C2780263894 @default.
• W2069933440 hasConcept C2780378348 @default.
• W2069933440 hasConcept C2781076698 @default.
• W2069933440 hasConcept C2781081902 @default.
• W2069933440 hasConcept C55493867 @default.
• W2069933440 hasConcept C58732023 @default.
• W2069933440 hasConcept C71240020 @default.
• W2069933440 hasConcept C89951826 @default.
• W2069933440 hasConceptScore W2069933440C111233374 @default.
• W2069933440 hasConceptScore W2069933440C114373084 @default.
• W2069933440 hasConceptScore W2069933440C155647269 @default.
• W2069933440 hasConceptScore W2069933440C168258287 @default.
• W2069933440 hasConceptScore W2069933440C170493617 @default.
• W2069933440 hasConceptScore W2069933440C178790620 @default.
• W2069933440 hasConceptScore W2069933440C185592680 @default.
• W2069933440 hasConceptScore W2069933440C202751555 @default.
• W2069933440 hasConceptScore W2069933440C2778173252 @default.
• W2069933440 hasConceptScore W2069933440C2778938600 @default.
• W2069933440 hasConceptScore W2069933440C2780263894 @default.
• W2069933440 hasConceptScore W2069933440C2780378348 @default.
• W2069933440 hasConceptScore W2069933440C2781076698 @default.
• W2069933440 hasConceptScore W2069933440C2781081902 @default.
• W2069933440 hasConceptScore W2069933440C55493867 @default.
• W2069933440 hasConceptScore W2069933440C58732023 @default.
• W2069933440 hasConceptScore W2069933440C71240020 @default.
• W2069933440 hasConceptScore W2069933440C89951826 @default.
• W2069933440 hasIssue "1" @default.
• W2069933440 hasLocation W20699334401 @default.

• next