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- W2069934239 abstract "Abstract Bone tumours induced in rats by repeated injections of 32P-orthophosphate exhibit morphological characteristics of osteogenic differentiation after successive transplantation; stromal mineralization is a constant feature. Cell membranes isolated from the transplantable tumour possess a parathyroid hormone (PTH) and prostaglandin (PGE1, PGE2, PGF2α) responsive adenylate cyclase. Basal cyclic AMP (cAMP) concentrations and PTH responsiveness are greatest in the cellular poorly mineralized peripheral zones of the tumour. cAMP and PTH induce a cytoplasmic contraction response in cultured tumour cells and the PTH responsive adenylate cyclase is retained by the cells even after repeated subculture. A direct correlation exists between tumour size and serum alkaline phosphatase activity." @default.
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- W2069934239 date "1979-09-01" @default.
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- W2069934239 title "Structural and functional correlations in parathyroid hormone responsive transplantable osteogenic sarcomas" @default.
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- W2069934239 doi "https://doi.org/10.1016/0014-2964(79)90131-2" @default.
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