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- W2069941772 abstract "Ca2+ influx through NMDA receptors can initiate molecular changes in neurones which may underlie synaptic plasticity, neuronal development, survival and excitotoxicity. Signalling through the MAP kinase (Erk1/2) cascade may be central to these processes. We previously demonstrated that Ca2+-permeable AMPA receptors activate Erkl/2 through a phosphatidylinositol 3-kinase (PI 3-kinase)-dependent mechanism. We now report that NMDA receptor activation of Erk1/2 was also blocked by inhibitors of PI 3-kinase (LY 294002, wortmannin). In addition, pre-treatment of neurones with pertussis toxin inhibited NMDA-induced Erk1/2 activation, indicating a role for heterotrimeric Gi/o proteins. PI 3-kinase directs activation of the serine-threonine kinase Akt (PKB). Treatment of striatal neurones with glutamate induced a rapid Ca2+-dependent and PI 3-kinase-dependent phosphorylation of Akt (Ser473), which was not blocked by the Mek inhibitors PD98059 or U0126. Targets for Erk1/2 and Akt pathways include transcription factors. Glutamate-induced phosphorylation of cAMP response element binding protein (CREB; Ser133) was partially blocked with either PD98059, U0126, LY294002 or wortmannin but was very strongly inhibited on co-application of LY294002 and PD98059. We propose that NMDA receptor stimulation can activate Erk1/2 and Akt signalling pathways in a PI 3-kinase dependent manner which may target CREB in the nucleus." @default.
- W2069941772 created "2016-06-24" @default.
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- W2069941772 creator A5076991869 @default.
- W2069941772 date "2002-01-01" @default.
- W2069941772 modified "2023-10-18" @default.
- W2069941772 title "Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones" @default.
- W2069941772 cites W1487207306 @default.
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- W2069941772 cites W1500368251 @default.
- W2069941772 cites W1528756081 @default.
- W2069941772 cites W1567065545 @default.
- W2069941772 cites W1584917605 @default.
- W2069941772 cites W1585517331 @default.
- W2069941772 cites W1595570385 @default.
- W2069941772 cites W1638203569 @default.
- W2069941772 cites W1660095449 @default.
- W2069941772 cites W1665109416 @default.
- W2069941772 cites W1934034828 @default.
- W2069941772 cites W1964486755 @default.
- W2069941772 cites W1971727526 @default.
- W2069941772 cites W1975513971 @default.
- W2069941772 cites W1976441097 @default.
- W2069941772 cites W1977237836 @default.
- W2069941772 cites W1977720833 @default.
- W2069941772 cites W1988844930 @default.
- W2069941772 cites W1989790828 @default.
- W2069941772 cites W1994720818 @default.
- W2069941772 cites W1994957003 @default.
- W2069941772 cites W2004123711 @default.
- W2069941772 cites W2006139248 @default.
- W2069941772 cites W2009387204 @default.
- W2069941772 cites W2012542103 @default.
- W2069941772 cites W2018581402 @default.
- W2069941772 cites W2024762752 @default.
- W2069941772 cites W2025148864 @default.
- W2069941772 cites W2025247587 @default.
- W2069941772 cites W2027847139 @default.
- W2069941772 cites W2034861130 @default.
- W2069941772 cites W2035936653 @default.
- W2069941772 cites W2036650593 @default.
- W2069941772 cites W2043878742 @default.
- W2069941772 cites W2044712342 @default.
- W2069941772 cites W2047826668 @default.
- W2069941772 cites W2048121649 @default.
- W2069941772 cites W2049367666 @default.
- W2069941772 cites W2053252892 @default.
- W2069941772 cites W2054414022 @default.
- W2069941772 cites W2056145172 @default.
- W2069941772 cites W2061894701 @default.
- W2069941772 cites W2064059449 @default.
- W2069941772 cites W2068225015 @default.
- W2069941772 cites W2077673188 @default.
- W2069941772 cites W2078102222 @default.
- W2069941772 cites W2080447903 @default.
- W2069941772 cites W2081524299 @default.
- W2069941772 cites W2087265687 @default.
- W2069941772 cites W2087444241 @default.
- W2069941772 cites W2091598446 @default.
- W2069941772 cites W2092014913 @default.
- W2069941772 cites W2095019608 @default.
- W2069941772 cites W2097293665 @default.
- W2069941772 cites W2097767970 @default.
- W2069941772 cites W2103002807 @default.
- W2069941772 cites W2103232698 @default.
- W2069941772 cites W2107258432 @default.
- W2069941772 cites W2107614388 @default.
- W2069941772 cites W2118977349 @default.
- W2069941772 cites W2124548597 @default.
- W2069941772 cites W2128960139 @default.
- W2069941772 cites W2132426150 @default.
- W2069941772 cites W2138141709 @default.
- W2069941772 cites W2138435646 @default.
- W2069941772 cites W2147114673 @default.
- W2069941772 cites W2155683150 @default.
- W2069941772 cites W2156655462 @default.
- W2069941772 cites W2162710298 @default.
- W2069941772 cites W2163302723 @default.
- W2069941772 cites W2164695495 @default.
- W2069941772 cites W2170891211 @default.
- W2069941772 cites W4235714311 @default.
- W2069941772 cites W4327766731 @default.
- W2069941772 doi "https://doi.org/10.1046/j.0022-3042.2001.00699.x" @default.
- W2069941772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11902114" @default.
- W2069941772 hasPublicationYear "2002" @default.
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