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- W2069941819 abstract "The Fc receptor complex and its associated phagocytic cytoskeleton machinery were captured from the surface of live cells by IgG coated microbeads and identified by mass spectrometry. The random and independently sampled intensity values of peptides were similar in the control and IgG samples. After log transformation, the parent and fragment intensity values showed a normal distribution where ≥99.9% of the data was well above the background noise. Some proteins showed significant differences in intensity between the IgG and control samples by ANOVA followed by the Tukey-Kramer honestly significant difference test. However many proteins were specific to the IgG beads or the control beads. The set of detected cytoskeleton proteins, binding proteins and enzymes detected on the IgG beads were used to predict the network of actin-associated regulatory factors. Signaling factors/proteins such as PIK3, PLC, GTPases (such CDC42, Rho GAPs/GEFs), annexins and inositol triphosphate receptors were all identified as being specific to the activated receptor complex by mass spectrometry. In addition, the tyrosine kinase Fak was detected with the IgG coated beads. Hence, an activated receptor cytoskeleton complex and its associated regulatory proteins were captured from the surface of live human primary leukocytes." @default.
- W2069941819 created "2016-06-24" @default.
- W2069941819 creator A5038789936 @default.
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- W2069941819 creator A5063977081 @default.
- W2069941819 creator A5067036077 @default.
- W2069941819 creator A5078546849 @default.
- W2069941819 date "2011-12-01" @default.
- W2069941819 modified "2023-10-18" @default.
- W2069941819 title "The Fc receptor-cytoskeleton complex from human neutrophils" @default.
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- W2069941819 doi "https://doi.org/10.1016/j.jprot.2011.08.011" @default.
- W2069941819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21911091" @default.
- W2069941819 hasPublicationYear "2011" @default.
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