FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069947991> ?p ?o ?g. }

• W2069947991 endingPage "1597" @default.
• W2069947991 startingPage "1589" @default.
• W2069947991 abstract "To assess the Y RNAs, a family of homologous RNAs that bind to the Ro autoantigen, for the ability to contribute to autoimmune disease by activating RNA-responsive Toll-like receptors (TLRs).Using cell lines expressing or stably transfected with TLR-3, TLR-7, or TLR-8, we determined the patterns of RNA-specific TLR activation by in vitro transcripts of all of the known murine and human Y RNAs. Next, 8-10-week-old female mice were exposed to a single 50-microg subcutaneous injection of mouse Y1 or mouse Y3 RNA, and the effects were observed.Y RNA family members differed in their TLR reactivities. Both human and mouse Y3 RNAs, but not other human or mouse Y RNAs, prominently induced TLR-3 activation. Although most human and mouse Y RNAs activated TLR-7 efficiently, mouse Y3 RNA and human Y5 RNA did not. Single subcutaneous injections of mice with either mouse Y1 RNA or mouse Y3 RNA induced or inhibited lymphoid infiltrates in different target organs based on the Y RNA and TLR status of the mouse used. Mouse Y1 RNA induced kidney lesions in TLR-3-intact mice but not in TLR-3-knockout mice. In contrast, mouse Y3 RNA treatment was associated with nephritis in TLR-3-knockout mice but not in TLR-3-intact mice. Sialoadenitis developed in untreated TLR-3-/- mice and in TLR-3-/- mice treated with mouse Y3 RNA, but sialoadenitis was not present in TLR--/-) mice treated with mouse Y1 RNA.Y RNAs can induce innate immune responses and influence clinical manifestations of autoimmunity, suggesting that they are relevant to syndromes of anti-Ro autoimmunity. Distinct patterns of tissue targeting can be seen after exposure to different Y RNAs, in a pattern that correlates with the innate immune signals they induce. Thus, the balance of innate immune signals induced by exposure to endogenous Y RNAs may help determine the nature of the clinical syndrome in anti-Ro autoimmunity." @default.
• W2069947991 created "2016-06-24" @default.
• W2069947991 creator A5006174263 @default.
• W2069947991 creator A5043861482 @default.
• W2069947991 creator A5047487268 @default.
• W2069947991 creator A5047950724 @default.
• W2069947991 creator A5048224451 @default.
• W2069947991 creator A5050436106 @default.
• W2069947991 creator A5071157898 @default.
• W2069947991 creator A5080668194 @default.
• W2069947991 date "2007-01-01" @default.
• W2069947991 modified "2023-10-16" @default.
• W2069947991 title "Differential tissue targeting of autoimmunity manifestations by Autoantigen-Associated Y RNAs" @default.
• W2069947991 cites W1610780465 @default.
• W2069947991 cites W1649848079 @default.
• W2069947991 cites W1943237394 @default.
• W2069947991 cites W1969346007 @default.
• W2069947991 cites W1973472843 @default.
• W2069947991 cites W1985148152 @default.
• W2069947991 cites W1985637111 @default.
• W2069947991 cites W1991814868 @default.
• W2069947991 cites W1992197229 @default.
• W2069947991 cites W1995871611 @default.
• W2069947991 cites W1999380065 @default.
• W2069947991 cites W2003790326 @default.
• W2069947991 cites W2018285828 @default.
• W2069947991 cites W2025980739 @default.
• W2069947991 cites W2026680566 @default.
• W2069947991 cites W2029184977 @default.
• W2069947991 cites W2029572135 @default.
• W2069947991 cites W2033170472 @default.
• W2069947991 cites W2034808278 @default.
• W2069947991 cites W2042721766 @default.
• W2069947991 cites W2049572705 @default.
• W2069947991 cites W2066004334 @default.
• W2069947991 cites W2070745233 @default.
• W2069947991 cites W2074478123 @default.
• W2069947991 cites W2078610240 @default.
• W2069947991 cites W2086801550 @default.
• W2069947991 cites W2097372881 @default.
• W2069947991 cites W2134106169 @default.
• W2069947991 cites W2134119588 @default.
• W2069947991 cites W2136811387 @default.
• W2069947991 cites W2139009442 @default.
• W2069947991 cites W2150882333 @default.
• W2069947991 cites W2161375720 @default.
• W2069947991 cites W2167814284 @default.
• W2069947991 doi "https://doi.org/10.1002/art.22601" @default.
• W2069947991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17469141" @default.
• W2069947991 hasPublicationYear "2007" @default.
• W2069947991 type Work @default.
• W2069947991 sameAs 2069947991 @default.
• W2069947991 citedByCount "19" @default.
• W2069947991 countsByYear W20699479912013 @default.
• W2069947991 countsByYear W20699479912014 @default.
• W2069947991 countsByYear W20699479912015 @default.
• W2069947991 countsByYear W20699479912016 @default.
• W2069947991 countsByYear W20699479912018 @default.
• W2069947991 countsByYear W20699479912019 @default.
• W2069947991 countsByYear W20699479912021 @default.
• W2069947991 countsByYear W20699479912023 @default.
• W2069947991 crossrefType "journal-article" @default.
• W2069947991 hasAuthorship W2069947991A5006174263 @default.
• W2069947991 hasAuthorship W2069947991A5043861482 @default.
• W2069947991 hasAuthorship W2069947991A5047487268 @default.
• W2069947991 hasAuthorship W2069947991A5047950724 @default.
• W2069947991 hasAuthorship W2069947991A5048224451 @default.
• W2069947991 hasAuthorship W2069947991A5050436106 @default.
• W2069947991 hasAuthorship W2069947991A5071157898 @default.
• W2069947991 hasAuthorship W2069947991A5080668194 @default.
• W2069947991 hasConcept C104317684 @default.
• W2069947991 hasConcept C153911025 @default.
• W2069947991 hasConcept C170493617 @default.
• W2069947991 hasConcept C182704531 @default.
• W2069947991 hasConcept C203014093 @default.
• W2069947991 hasConcept C2780130043 @default.
• W2069947991 hasConcept C54355233 @default.
• W2069947991 hasConcept C67705224 @default.
• W2069947991 hasConcept C86803240 @default.
• W2069947991 hasConcept C8891405 @default.
• W2069947991 hasConceptScore W2069947991C104317684 @default.
• W2069947991 hasConceptScore W2069947991C153911025 @default.
• W2069947991 hasConceptScore W2069947991C170493617 @default.
• W2069947991 hasConceptScore W2069947991C182704531 @default.
• W2069947991 hasConceptScore W2069947991C203014093 @default.
• W2069947991 hasConceptScore W2069947991C2780130043 @default.
• W2069947991 hasConceptScore W2069947991C54355233 @default.
• W2069947991 hasConceptScore W2069947991C67705224 @default.
• W2069947991 hasConceptScore W2069947991C86803240 @default.
• W2069947991 hasConceptScore W2069947991C8891405 @default.
• W2069947991 hasIssue "5" @default.
• W2069947991 hasLocation W20699479911 @default.
• W2069947991 hasLocation W20699479912 @default.
• W2069947991 hasOpenAccess W2069947991 @default.
• W2069947991 hasPrimaryLocation W20699479911 @default.
• W2069947991 hasRelatedWork W131625799 @default.
• W2069947991 hasRelatedWork W2025933940 @default.
• W2069947991 hasRelatedWork W2039151651 @default.

• next