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- W2069949576 abstract "Pancreatectomy as well as thyroparathyroidectomy resulted in the quick disappearance of a serum factor (stimulating cathepsin D release from lysosomes in vitro) from the rat or mouse blood. Extirpation of other organs such as duodenum, stomach, spleen, kidney, submaxillary gland, testis, adrenal gland or hypophysis, showed no effect on the serum factor level. Glucagon (but not insulin or thyroxine) given to the pancreatectomized animals restored the serum factor level in a dose-dependent manner. The serum factor-like activity was detected only in the parathyroids (but not thyroid), and the release of activity from parathyroid-slices was stimulated by glucagon, suggesting that the parathyroid may produce and/or secrete the serum factor under the influence of glucagon." @default.
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- W2069949576 date "1984-01-01" @default.
- W2069949576 modified "2023-10-17" @default.
- W2069949576 title "Tissue producing the serum factor stimulating the release of cathepsin D from lysosomes in vitro." @default.
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- W2069949576 doi "https://doi.org/10.1016/0300-9629(84)90008-2" @default.
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