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• W2069955906 abstract "Fibroblast growth factors (FGFs) mediate cell growth, differentiation, migration, and morphogenesis by binding to the extracellular domain of cell surface receptors, triggering receptor tyrosine phosphorylation and signal transduction [1Basilico C. Moscatelli D. The FGF family of growth factors and oncogenes.Adv Cancer Res. 1992; 59: 115-165Crossref PubMed Scopus (1035) Google Scholar, 2Goldfarb M. Functions of FGFs in vertebrate development.Cytokine Growth Factor Rev. 1996; 7: 311-325Abstract Full Text PDF PubMed Scopus (203) Google Scholar, 3Coulier F. Pontarotti P. Roubin R. Hartung H. Goldfarb M. Birnbaum D. Of worms and men an evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families.J Mol Evol. 1997; 44: 43-56Crossref PubMed Scopus (183) Google Scholar, 4Bellot F. Crumley G. Kaplow J.M. Schlessinger J. Jaye M. Dionne C.A. Ligand-induced transphosphorylation between different FGF receptors.EMBO J. 1991; 10: 2849-2854Crossref PubMed Scopus (158) Google Scholar, 5Ornitz D.M. Xu J. Colvin J.S. McEwen D.G. MacArthur C.A. Coulier F. et al.Receptor specificity of the fibroblast growth factor family.J Biol Chem. 1996; 271: 15292-15297Crossref PubMed Scopus (1362) Google Scholar]. FGF homologous factors (FHFs) were discovered within vertebrate DNA sequence databases by virtue of their sequence similarity to FGFs [3Coulier F. Pontarotti P. Roubin R. Hartung H. Goldfarb M. Birnbaum D. Of worms and men an evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families.J Mol Evol. 1997; 44: 43-56Crossref PubMed Scopus (183) Google Scholar, 6Smallwood P.M. Munoz-Sanjuan I. Tong P. Macke J.P. Hendry S.H. Gilbert D.J. et al.Fibroblast growth factor (FGF) homologous factors new members of the FGF family implicated in nervous system development.Proc Natl Acad Sci USA. 1996; 93: 9850-9857Crossref PubMed Scopus (318) Google Scholar, 7Hartung H. Feldman B. Lovec H. Coulier F. Birnbaum D. Goldfarb M. Murine FGF-12 and FGF-13 expression in embryonic nervous system, connective tissue and heart.Mech Dev. 1997; 64: 31-39Crossref PubMed Scopus (98) Google Scholar], but the mechanism of FHF action has not been reported. We show here that FHF-1 is associated with the MAP kinase (MAPK) scaffold protein Islet-Brain-2 (IB2) [8Negri S. Oberson A. Steinmann M. Sauser C. Nicod P. Waeber G. et al.cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.Genomics. 2000; 64: 324-330Crossref PubMed Scopus (56) Google Scholar] in the brain and in specific cell lines. FHF/IB2 interaction is highly specific, as FHFs do not bind to the related scaffold protein IB1(JIP-1b) [9Whitmarsh A.J. Cavanagh J. Tournier C. Yasuda J. Davis R.J. A mammalian scaffold complex that selectively mediates MAP kinase activation.Science. 1998; 281: 1671-1674Crossref PubMed Scopus (573) Google Scholar, 10Bonny C. Nicod P. Waeber G. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells.J Biol Chem. 1998; 273: 1843-1846Crossref PubMed Scopus (135) Google Scholar], nor can FGF-1 bind to IB2. We further show that FHFs enable IB2 to recruit a specific MAPK in transfected cells, and our data suggest that the scaffolds IB1 and IB2 have different MAPK specificities. Hence, FHFs are intracellular components of a tissue-specific protein kinase signaling module." @default.
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• W2069955906 date "2001-05-01" @default.
• W2069955906 modified "2023-10-11" @default.
• W2069955906 title "Fibroblast growth factor homologous factors are intracellular signaling proteins" @default.
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• W2069955906 doi "https://doi.org/10.1016/s0960-9822(01)00232-9" @default.
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