FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069958139> ?p ?o ?g. }

• W2069958139 endingPage "191" @default.
• W2069958139 startingPage "185" @default.
• W2069958139 abstract "Posttranslational processing of vitamin K-dependent proteins includes gamma-carboxylation of specific glutamic acid residues to form gamma-carboxyglutamic acids. To determine whether carboxylation is directed by the propeptide sequence, homologous among the precursors of these proteins, alterations were made in the Factor IX propeptide cDNA. The extent of gamma-carboxylation of recombinant Factor IX was assessed using conformation-specific antibodies directed against the gamma-carboxyglutamic acid-dependent, metal-stabilized structure. Deletion of the propeptide (residues -18 to -1) abolished carboxylation, but not secretion, of Factor IX. Substitution of alanine for phenylalanine -16 or glutamic acid for alanine -10 also impaired carboxylation. These results indicate that the Factor IX propeptide participates in defining a recognition site that designates an adjacent glutamic acid-rich domain for gamma-carboxylation. The association of the propeptide with the gamma-carboxylation recognition site provides the first demonstration of a specific function served by a propeptide in posttranslational protein processing." @default.
• W2069958139 created "2016-06-24" @default.
• W2069958139 creator A5013154884 @default.
• W2069958139 creator A5050661762 @default.
• W2069958139 creator A5050970118 @default.
• W2069958139 creator A5057286617 @default.
• W2069958139 creator A5066321804 @default.
• W2069958139 creator A5077133720 @default.
• W2069958139 date "1987-01-01" @default.
• W2069958139 modified "2023-10-10" @default.
• W2069958139 title "Recognition site directing vitamin K-dependent γ-carboxylation resides on the propeptide of factor IX" @default.
• W2069958139 cites W1487857339 @default.
• W2069958139 cites W1509651969 @default.
• W2069958139 cites W1517385423 @default.
• W2069958139 cites W1524957948 @default.
• W2069958139 cites W1542609899 @default.
• W2069958139 cites W1576256885 @default.
• W2069958139 cites W1577210936 @default.
• W2069958139 cites W1782728159 @default.
• W2069958139 cites W1966845579 @default.
• W2069958139 cites W1971560358 @default.
• W2069958139 cites W1973963051 @default.
• W2069958139 cites W1988808109 @default.
• W2069958139 cites W1996834952 @default.
• W2069958139 cites W2012233916 @default.
• W2069958139 cites W2013456957 @default.
• W2069958139 cites W2014321630 @default.
• W2069958139 cites W2032275395 @default.
• W2069958139 cites W2036945914 @default.
• W2069958139 cites W2057612752 @default.
• W2069958139 cites W2060013497 @default.
• W2069958139 cites W2100837269 @default.
• W2069958139 cites W2111800688 @default.
• W2069958139 cites W2201473605 @default.
• W2069958139 cites W4240283855 @default.
• W2069958139 cites W4253707973 @default.
• W2069958139 cites W5358143 @default.
• W2069958139 cites W98911413 @default.
• W2069958139 doi "https://doi.org/10.1016/0092-8674(87)90422-3" @default.
• W2069958139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3802193" @default.
• W2069958139 hasPublicationYear "1987" @default.
• W2069958139 type Work @default.
• W2069958139 sameAs 2069958139 @default.
• W2069958139 citedByCount "194" @default.
• W2069958139 countsByYear W20699581392014 @default.
• W2069958139 countsByYear W20699581392015 @default.
• W2069958139 countsByYear W20699581392017 @default.
• W2069958139 countsByYear W20699581392018 @default.
• W2069958139 countsByYear W20699581392019 @default.
• W2069958139 countsByYear W20699581392020 @default.
• W2069958139 countsByYear W20699581392021 @default.
• W2069958139 countsByYear W20699581392022 @default.
• W2069958139 crossrefType "journal-article" @default.
• W2069958139 hasAuthorship W2069958139A5013154884 @default.
• W2069958139 hasAuthorship W2069958139A5050661762 @default.
• W2069958139 hasAuthorship W2069958139A5050970118 @default.
• W2069958139 hasAuthorship W2069958139A5057286617 @default.
• W2069958139 hasAuthorship W2069958139A5066321804 @default.
• W2069958139 hasAuthorship W2069958139A5077133720 @default.
• W2069958139 hasConcept C104317684 @default.
• W2069958139 hasConcept C161790260 @default.
• W2069958139 hasConcept C167625842 @default.
• W2069958139 hasConcept C181199279 @default.
• W2069958139 hasConcept C24428623 @default.
• W2069958139 hasConcept C2778740566 @default.
• W2069958139 hasConcept C2779281246 @default.
• W2069958139 hasConcept C2779856020 @default.
• W2069958139 hasConcept C515207424 @default.
• W2069958139 hasConcept C55493867 @default.
• W2069958139 hasConcept C7860815 @default.
• W2069958139 hasConcept C86803240 @default.
• W2069958139 hasConceptScore W2069958139C104317684 @default.
• W2069958139 hasConceptScore W2069958139C161790260 @default.
• W2069958139 hasConceptScore W2069958139C167625842 @default.
• W2069958139 hasConceptScore W2069958139C181199279 @default.
• W2069958139 hasConceptScore W2069958139C24428623 @default.
• W2069958139 hasConceptScore W2069958139C2778740566 @default.
• W2069958139 hasConceptScore W2069958139C2779281246 @default.
• W2069958139 hasConceptScore W2069958139C2779856020 @default.
• W2069958139 hasConceptScore W2069958139C515207424 @default.
• W2069958139 hasConceptScore W2069958139C55493867 @default.
• W2069958139 hasConceptScore W2069958139C7860815 @default.
• W2069958139 hasConceptScore W2069958139C86803240 @default.
• W2069958139 hasIssue "2" @default.
• W2069958139 hasLocation W20699581391 @default.
• W2069958139 hasLocation W20699581392 @default.
• W2069958139 hasOpenAccess W2069958139 @default.
• W2069958139 hasPrimaryLocation W20699581391 @default.
• W2069958139 hasRelatedWork W1964899152 @default.
• W2069958139 hasRelatedWork W2030074235 @default.
• W2069958139 hasRelatedWork W2069958139 @default.
• W2069958139 hasRelatedWork W2309489207 @default.
• W2069958139 hasRelatedWork W2351136315 @default.
• W2069958139 hasRelatedWork W2409862710 @default.
• W2069958139 hasRelatedWork W2481348576 @default.
• W2069958139 hasRelatedWork W3090799731 @default.
• W2069958139 hasRelatedWork W3173044593 @default.
• W2069958139 hasRelatedWork W4255682201 @default.

• next