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- W2069958360 endingPage "452" @default.
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- W2069958360 abstract "Many natural products contain carbohydrate moieties that contribute to their biological activity. Manipulation of the carbohydrate domain of natural products through multiple glycosylations to identify new derivatives with novel biological activities has been a difficult and impractical process. We report a practical one-pot enzymatic approach with regeneration of cosubstrates to synthesize analogues of vancomycin that contain an N-alkyl glucosamine, which exhibited marked improvement in antibiotic activity against a vancomycin-resistant strain of Enterococcus." @default.
- W2069958360 created "2016-06-24" @default.
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- W2069958360 date "2006-09-18" @default.
- W2069958360 modified "2023-10-17" @default.
- W2069958360 title "Vancomycin Analogues Containing Monosaccharides Exhibit Improved Antibiotic Activity: A Combined One-Pot Enzymatic Glycosylation and Chemical Diversification Strategy" @default.
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- W2069958360 doi "https://doi.org/10.1002/asia.200600084" @default.
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