FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069965245> ?p ?o ?g. }

• W2069965245 endingPage "990" @default.
• W2069965245 startingPage "983" @default.
• W2069965245 abstract "To study the molecular basis for the emergence of human immunodeficiency virus type 1 (HIV-1) variants with reduced sensitivity to neutralization by autologous sera, the DNA sequence of the envelope V3 loop was determined in HIV-1 isolates derived from four patients with primary HIV-1 infection and sequentially thereafter. The gene fragment encoding the V3 loop of gp120 was amplified by a nested polymerase chain reaction (PCR) and subsequently sequenced by a novel solid phase DNA sequencing approach allowing direct sequencing of the viral genome without the need for previous cloning. The results show that all patients have HIV-1 with unique primary sequence of the V3 loop and antibodies to this structure are produced at seroconversion. The structural analysis also demonstrates that the mechanism for virus escape from neutralization in vivo is complex. Thus, in one patient the emergence of neutralization-resistant viruses coincided with the introduction of several amino acid changes in the V3 loop, while in two other patients the V3 loop remained completely unchanged. These Findings suggest that an understanding of the interaction between the humoral immune response and HIV-1 may require detailed structural studies of the entire envelope." @default.
• W2069965245 created "2016-06-24" @default.
• W2069965245 creator A5000893028 @default.
• W2069965245 creator A5002111248 @default.
• W2069965245 creator A5039557415 @default.
• W2069965245 creator A5054656710 @default.
• W2069965245 creator A5055195187 @default.
• W2069965245 creator A5060241561 @default.
• W2069965245 creator A5061200353 @default.
• W2069965245 creator A5069056857 @default.
• W2069965245 date "1991-12-01" @default.
• W2069965245 modified "2023-10-18" @default.
• W2069965245 title "Analysis of the V3 Loop in Neutralization-Resistant Human Immunodeficiency Virus Type 1 Variants by Direct Solid-Phase DNA Sequencing" @default.
• W2069965245 cites W1485928263 @default.
• W2069965245 cites W1514857866 @default.
• W2069965245 cites W1610555304 @default.
• W2069965245 cites W1768734130 @default.
• W2069965245 cites W1912026111 @default.
• W2069965245 cites W1920597859 @default.
• W2069965245 cites W1971333195 @default.
• W2069965245 cites W1974138678 @default.
• W2069965245 cites W1976564230 @default.
• W2069965245 cites W1981026726 @default.
• W2069965245 cites W1982794770 @default.
• W2069965245 cites W1992647629 @default.
• W2069965245 cites W2000341889 @default.
• W2069965245 cites W2006261548 @default.
• W2069965245 cites W2009655331 @default.
• W2069965245 cites W2041392515 @default.
• W2069965245 cites W2047819393 @default.
• W2069965245 cites W2048574795 @default.
• W2069965245 cites W2051549118 @default.
• W2069965245 cites W2054724326 @default.
• W2069965245 cites W2059599036 @default.
• W2069965245 cites W2066574980 @default.
• W2069965245 cites W2068815236 @default.
• W2069965245 cites W2084341498 @default.
• W2069965245 cites W2088403913 @default.
• W2069965245 cites W2094954825 @default.
• W2069965245 cites W2097238654 @default.
• W2069965245 cites W2110279018 @default.
• W2069965245 cites W2131626832 @default.
• W2069965245 cites W2137966586 @default.
• W2069965245 cites W2405311099 @default.
• W2069965245 doi "https://doi.org/10.1089/aid.1991.7.983" @default.
• W2069965245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1812947" @default.
• W2069965245 hasPublicationYear "1991" @default.
• W2069965245 type Work @default.
• W2069965245 sameAs 2069965245 @default.
• W2069965245 citedByCount "42" @default.
• W2069965245 crossrefType "journal-article" @default.
• W2069965245 hasAuthorship W2069965245A5000893028 @default.
• W2069965245 hasAuthorship W2069965245A5002111248 @default.
• W2069965245 hasAuthorship W2069965245A5039557415 @default.
• W2069965245 hasAuthorship W2069965245A5054656710 @default.
• W2069965245 hasAuthorship W2069965245A5055195187 @default.
• W2069965245 hasAuthorship W2069965245A5060241561 @default.
• W2069965245 hasAuthorship W2069965245A5061200353 @default.
• W2069965245 hasAuthorship W2069965245A5069056857 @default.
• W2069965245 hasConcept C104317684 @default.
• W2069965245 hasConcept C14086860 @default.
• W2069965245 hasConcept C157431215 @default.
• W2069965245 hasConcept C159047783 @default.
• W2069965245 hasConcept C167625842 @default.
• W2069965245 hasConcept C2522874641 @default.
• W2069965245 hasConcept C2777451964 @default.
• W2069965245 hasConcept C2779921545 @default.
• W2069965245 hasConcept C49105822 @default.
• W2069965245 hasConcept C54355233 @default.
• W2069965245 hasConcept C552990157 @default.
• W2069965245 hasConcept C84148353 @default.
• W2069965245 hasConcept C86803240 @default.
• W2069965245 hasConceptScore W2069965245C104317684 @default.
• W2069965245 hasConceptScore W2069965245C14086860 @default.
• W2069965245 hasConceptScore W2069965245C157431215 @default.
• W2069965245 hasConceptScore W2069965245C159047783 @default.
• W2069965245 hasConceptScore W2069965245C167625842 @default.
• W2069965245 hasConceptScore W2069965245C2522874641 @default.
• W2069965245 hasConceptScore W2069965245C2777451964 @default.
• W2069965245 hasConceptScore W2069965245C2779921545 @default.
• W2069965245 hasConceptScore W2069965245C49105822 @default.
• W2069965245 hasConceptScore W2069965245C54355233 @default.
• W2069965245 hasConceptScore W2069965245C552990157 @default.
• W2069965245 hasConceptScore W2069965245C84148353 @default.
• W2069965245 hasConceptScore W2069965245C86803240 @default.
• W2069965245 hasIssue "12" @default.
• W2069965245 hasLocation W20699652451 @default.
• W2069965245 hasLocation W20699652452 @default.
• W2069965245 hasOpenAccess W2069965245 @default.
• W2069965245 hasPrimaryLocation W20699652451 @default.
• W2069965245 hasRelatedWork W1493673711 @default.
• W2069965245 hasRelatedWork W1937592616 @default.
• W2069965245 hasRelatedWork W1964842398 @default.
• W2069965245 hasRelatedWork W1967083729 @default.
• W2069965245 hasRelatedWork W1974138678 @default.
• W2069965245 hasRelatedWork W2056420846 @default.
• W2069965245 hasRelatedWork W2058074887 @default.
• W2069965245 hasRelatedWork W2104487408 @default.

• next