FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069967701> ?p ?o ?g. }

• W2069967701 endingPage "422" @default.
• W2069967701 startingPage "415" @default.
• W2069967701 abstract "A factor stimulating a mitogenic activity of peritoneal macrophages is purified from bovine udder. It is identified as a triglyceride, 1-palmitoyl-2-linoleoyl-3-acetyl-RAC -glycerol (RAC -MADG). In this study, its enantiomers, R-(+)-and S-(-)-1-palmitoyl-2-linoleoyl-3-acetylglycerol (R-(+)-MADG, S-(-)-MADG) are synthesized. Among them, R-(+)-MADG enantiomer turns out to increase a mitogenic activity in mouse peritoneal macrophages. Also, (S)-(-)-MADG shows a low mitogenic activity. Treatment of a macrophage with R-(+)-MADG increases reactive oxygen species(ROS). Furthermore, treatment of macrophages with antioxidant, N-acetyl-L-cysteine (NAC), suppresses the R-(+)-MADG-dependent macrophage proliferation. Results show that the generation of ROS induces in R-(+)-MADG-dependent cell signaling. Treatment of a macrophage with R-(+)-MADG increases the activity of protein kinase C (PKC). Treatment of macrophages with calphostin C inhibits R-(+)-MADG-induced macrophage proliferation. Results suggest that R-(+)-MADG enhances the activity of protein kinase C (PKC) and stimulates the macrophage growth. In conclusions, R-(+)-MADG accelerates the production of ROS and increases the activity of PKC to eventually stimulate macrophage cell growth. The existence of RAC -MADG in bovine udder and milk provides passive protection for the neonate and immunostimulatory capabilities." @default.
• W2069967701 created "2016-06-24" @default.
• W2069967701 creator A5017000646 @default.
• W2069967701 creator A5022011748 @default.
• W2069967701 creator A5034124080 @default.
• W2069967701 creator A5034885473 @default.
• W2069967701 creator A5047050899 @default.
• W2069967701 creator A5048213027 @default.
• W2069967701 creator A5051495748 @default.
• W2069967701 creator A5066397590 @default.
• W2069967701 creator A5076566352 @default.
• W2069967701 date "2003-01-01" @default.
• W2069967701 modified "2023-09-26" @default.
• W2069967701 title "Triacylglycerol, 1-Palmitoyl-2-Linoleoyl-3-Acetyl-<i>rac </i> -Glycerol Isolated from Bovine Udder and its Synthetic Enantiomer can Potentiate the Mitogenic Activity for Mouse Peritoneal Macrophages" @default.
• W2069967701 cites W1702502334 @default.
• W2069967701 cites W1907097296 @default.
• W2069967701 cites W1934775191 @default.
• W2069967701 cites W1964603858 @default.
• W2069967701 cites W1980199287 @default.
• W2069967701 cites W2000586934 @default.
• W2069967701 cites W2015042570 @default.
• W2069967701 cites W2019023424 @default.
• W2069967701 cites W2028818216 @default.
• W2069967701 cites W2031049343 @default.
• W2069967701 cites W2032140041 @default.
• W2069967701 cites W2037959031 @default.
• W2069967701 cites W2039588224 @default.
• W2069967701 cites W2043544340 @default.
• W2069967701 cites W2043811909 @default.
• W2069967701 cites W2061152334 @default.
• W2069967701 cites W2082191320 @default.
• W2069967701 cites W2083316920 @default.
• W2069967701 cites W2087766001 @default.
• W2069967701 cites W2091671423 @default.
• W2069967701 cites W2104251051 @default.
• W2069967701 cites W2106667710 @default.
• W2069967701 cites W2114918609 @default.
• W2069967701 cites W2136573391 @default.
• W2069967701 cites W2143811153 @default.
• W2069967701 cites W2149571807 @default.
• W2069967701 cites W2337457656 @default.
• W2069967701 cites W27333232 @default.
• W2069967701 doi "https://doi.org/10.1159/000075129" @default.
• W2069967701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14631148" @default.
• W2069967701 hasPublicationYear "2003" @default.
• W2069967701 type Work @default.
• W2069967701 sameAs 2069967701 @default.
• W2069967701 citedByCount "7" @default.
• W2069967701 countsByYear W20699677012014 @default.
• W2069967701 countsByYear W20699677012016 @default.
• W2069967701 countsByYear W20699677012022 @default.
• W2069967701 crossrefType "journal-article" @default.
• W2069967701 hasAuthorship W2069967701A5017000646 @default.
• W2069967701 hasAuthorship W2069967701A5022011748 @default.
• W2069967701 hasAuthorship W2069967701A5034124080 @default.
• W2069967701 hasAuthorship W2069967701A5034885473 @default.
• W2069967701 hasAuthorship W2069967701A5047050899 @default.
• W2069967701 hasAuthorship W2069967701A5048213027 @default.
• W2069967701 hasAuthorship W2069967701A5051495748 @default.
• W2069967701 hasAuthorship W2069967701A5066397590 @default.
• W2069967701 hasAuthorship W2069967701A5076566352 @default.
• W2069967701 hasConcept C153911025 @default.
• W2069967701 hasConcept C184235292 @default.
• W2069967701 hasConcept C195794163 @default.
• W2069967701 hasConcept C202751555 @default.
• W2069967701 hasConcept C2779244956 @default.
• W2069967701 hasConcept C2781168148 @default.
• W2069967701 hasConcept C48349386 @default.
• W2069967701 hasConcept C55493867 @default.
• W2069967701 hasConcept C86803240 @default.
• W2069967701 hasConcept C97029542 @default.
• W2069967701 hasConceptScore W2069967701C153911025 @default.
• W2069967701 hasConceptScore W2069967701C184235292 @default.
• W2069967701 hasConceptScore W2069967701C195794163 @default.
• W2069967701 hasConceptScore W2069967701C202751555 @default.
• W2069967701 hasConceptScore W2069967701C2779244956 @default.
• W2069967701 hasConceptScore W2069967701C2781168148 @default.
• W2069967701 hasConceptScore W2069967701C48349386 @default.
• W2069967701 hasConceptScore W2069967701C55493867 @default.
• W2069967701 hasConceptScore W2069967701C86803240 @default.
• W2069967701 hasConceptScore W2069967701C97029542 @default.
• W2069967701 hasIssue "6" @default.
• W2069967701 hasLocation W20699677011 @default.
• W2069967701 hasLocation W20699677012 @default.
• W2069967701 hasOpenAccess W2069967701 @default.
• W2069967701 hasPrimaryLocation W20699677011 @default.
• W2069967701 hasRelatedWork W1969797053 @default.
• W2069967701 hasRelatedWork W1970678244 @default.
• W2069967701 hasRelatedWork W1984042705 @default.
• W2069967701 hasRelatedWork W2037800788 @default.
• W2069967701 hasRelatedWork W2048232359 @default.
• W2069967701 hasRelatedWork W2082141855 @default.
• W2069967701 hasRelatedWork W2087180291 @default.
• W2069967701 hasRelatedWork W2099351483 @default.
• W2069967701 hasRelatedWork W2123488059 @default.
• W2069967701 hasRelatedWork W2319455371 @default.
• W2069967701 hasVolume "13" @default.
• W2069967701 isParatext "false" @default.

• next