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• W2069968362 abstract "Apolipoprotein AI (apoAI) is a lipid-binding protein that participates in the transport of cholesterol and other lipids in the plasma. A complementary DNA clone for a protein that bound to regulatory elements of the apoAI gene was isolated. This protein, designated apoAI regulatory protein-1 (ARP-1), is a novel member of the steroid hormone receptor superfamily. ARP-1 bound to DNA as a dimer, and its dimerization domain was localized to the COOH-terminal region. ARP-1 also bound to a thyroid hormone-responsive element and to regulatory regions of the apoB, apoCIII, insulin, and ovalbumin genes. In cotransfection experiments, ARP-1 downregulated the apoAI gene. The involvement of ARP-1 in the regulation of apoAI gene expression suggests that it may participate in lipid metabolism and cholesterol homeostasis." @default.
• W2069968362 created "2016-06-24" @default.
• W2069968362 creator A5029146873 @default.
• W2069968362 creator A5083711980 @default.
• W2069968362 date "1991-02-01" @default.
• W2069968362 modified "2023-10-16" @default.
• W2069968362 title "Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily" @default.
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• W2069968362 doi "https://doi.org/10.1126/science.1899293" @default.
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