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- W2069968806 abstract "Interleukin 1 beta (IL-1beta) is often associated with thyroidal autoimmune diseases. This cytokine has been largely described to trigger an important biological signalling pathway: the sphingomyelin/ceramide pathway. In this report we show that IL-1beta induces ceramide formation and sphingomyelin degradation in porcine thyroid cells via the activation of a neutral sphingomyelinase. Among the potential targets of IL-1beta and ceramides action, we have investigated the role of an atypical protein kinase C (PKC), the PKC zeta. We show that both IL-1beta and ceramides lead to an increase of PKCzeta activity. All these results suggest an important role for ceramides and IL-1beta in regulation of thyroid function, leading to cell survival or to apoptosis." @default.
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- W2069968806 date "2001-02-01" @default.
- W2069968806 modified "2023-09-25" @default.
- W2069968806 title "INTERLEUKIN 1β (IL-1β) ACTION IN PORCINE THYROID CELLS INVOLVES THE CERAMIDE SIGNALLING PATHWAY" @default.
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- W2069968806 doi "https://doi.org/10.1006/cyto.2000.0817" @default.
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