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- W2069969643 abstract "Neurochemical changes were examined in dopamine D1 receptor knockout (D1−/−), dopamine D3 receptor knockout (D3−/−) and dopamine D1/D3 receptor double knockout (D1−/−D3−/−) mice. The level of dopamine D1- and D2-like receptors and γ-aminobutyric acid (GABAA) receptor was assessed by ligand autoradiography and dopamine D1- and D2 receptor, enkephalin, dynorphin and substance P transcripts measured by in situ hybridization. D1−/− mice had normal GABAA receptor levels, reduced dynorphin and substance P, and increased enkephalin mRNA and dopamine D2-like binding. D1−/−D3−/− mice evidenced decreased dynorphin and substance P but normal enkephalin expression, whereas dopamine D2-like and GABAA receptor binding were increased. Major changes occur in substance P and dynorphin expression in D1−/− mice and these changes are unaffected by loss of dopamine D3 receptors. Upregulated dopamine D2-like binding and enkephalin in D1−/− mice may be due to decreased dopamine turnover. Upregulated enkephalin in D1−/− mice is dependent on functional dopamine D3 receptors." @default.
- W2069969643 created "2016-06-24" @default.
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- W2069969643 date "2003-07-01" @default.
- W2069969643 modified "2023-10-10" @default.
- W2069969643 title "Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice" @default.
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- W2069969643 doi "https://doi.org/10.1016/s0014-2999(03)01862-4" @default.
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