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- W2069970859 abstract "Elucidating the mechanisms whereby neuroendocrine tissues coordinate their input and output signals to ensure appropriate hormone secretion is currently a topical issue. In particular, whether a direct communication mediated by gap junctions between neurosecretory cells contributes to hormone release in vivo still remains unknown. Here we address this issue using a microsurgical approach allowing combined monitoring of adrenal catecholamine secretion and splanchnic nerve stimulation in anaesthetised mice. Pharmacological blockade of adrenal gap junctions by the uncoupling agent carbenoxolone reduces nerve stimulation-evoked catecholamine release in control mice and to a larger extent in stressed mice. In parallel, the gap junction-coupled cell network is extended in stressed mice. Altogether, this argues for a significant contribution of adrenomedullary gap junctions to catecholamine secretion in vivo. As such, gap junctional signalling appears to be a substantial component for neuroendocrine function in the adrenal medulla, as it may represent an additional lever regulating hormone release." @default.
- W2069970859 created "2016-06-24" @default.
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- W2069970859 date "2013-12-20" @default.
- W2069970859 modified "2023-10-15" @default.
- W2069970859 title "Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo" @default.
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- W2069970859 doi "https://doi.org/10.1038/ncomms3938" @default.
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