FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069971283> ?p ?o ?g. }

• W2069971283 endingPage "222" @default.
• W2069971283 startingPage "213" @default.
• W2069971283 abstract "The role of mitochondrial transporters in the cardioprotection of rat hearts exposed to high [K+]-low [Ca2+]-cardioplegia (CPG) and ischemia and reperfusion (I/R) was studied through the mechano-energetic consequences of target drugs. The total heat rate (Ht) and the left intraventricular pressure (LVP) were simultaneously measured in isolated perfused hearts (30 degrees C and 1 Hz) inside a flow-calorimeter during 45 minutes of no-flow I and 45 minutes of R. After stabilization (C) they were pretreated with CPG and 100 microM 5-hydroxidecanoate (5HD, selective mKATP blocker) without and with 10 or 30 microM clonazepam (Clzp, mNCX inhibitor), 30 microM diazoxide (Dzx, selective mKATP opener), 1 microM Ru360 (selective Ca-uniporter blocker), and 0.2 microM cyclosporine-A, (mPTP inhibitor, before I and during R). Before I, 5-hydroxydecanoate in CPG increased the resting heat rate (17.83 +/- 3.55 mW/g) without changing the stunning. Clzp 30 microM + CPG + 5-hydroxydecanoate reduced the postischemic P with diastolic contracture and high Ht. Dzx protected C-hearts from stunning but increased it in CPG hearts with low economy (P/Ht) as well as Ru360. Cyclosporine-A did not modify the stunning of C or CPG ischemic hearts, suggesting that the mPTP was not opened.Mitochondria have a precise role for determining cardioprotection or stunning in high-K+ cardioplegic rat hearts under I/R. Known protective drugs, such as Dzx and Ru360, which reduce the mitochondrial Ca2+-uptake, increased the stunning of CPG-rat hearts and reduced muscle economy, whereas 5-hydroxydecanoate and Clzp together increased the stunning by inducing mitochondrial Ca2+ overload." @default.
• W2069971283 created "2016-06-24" @default.
• W2069971283 creator A5040996296 @default.
• W2069971283 creator A5067820688 @default.
• W2069971283 date "2009-09-01" @default.
• W2069971283 modified "2023-10-07" @default.
• W2069971283 title "CARDIAC Role of the Mitochondrial Ca2+ Transporters in the High-[K+]o Cardioprotection of Rat Hearts Under Ischemia and Reperfusion: A Mechano-Energetic Study" @default.
• W2069971283 cites W1543560706 @default.
• W2069971283 cites W1851055496 @default.
• W2069971283 cites W1934994215 @default.
• W2069971283 cites W1966737769 @default.
• W2069971283 cites W1983653661 @default.
• W2069971283 cites W1996867825 @default.
• W2069971283 cites W1999631310 @default.
• W2069971283 cites W2010362120 @default.
• W2069971283 cites W2011128997 @default.
• W2069971283 cites W2018611729 @default.
• W2069971283 cites W2028463380 @default.
• W2069971283 cites W2034226602 @default.
• W2069971283 cites W2035586756 @default.
• W2069971283 cites W2039515832 @default.
• W2069971283 cites W2046130992 @default.
• W2069971283 cites W2051790575 @default.
• W2069971283 cites W2059869395 @default.
• W2069971283 cites W2060381862 @default.
• W2069971283 cites W2062795731 @default.
• W2069971283 cites W2063830130 @default.
• W2069971283 cites W2068048197 @default.
• W2069971283 cites W2072982083 @default.
• W2069971283 cites W2086351664 @default.
• W2069971283 cites W2086675887 @default.
• W2069971283 cites W2100405364 @default.
• W2069971283 cites W2108794906 @default.
• W2069971283 cites W2111975835 @default.
• W2069971283 cites W2115928291 @default.
• W2069971283 cites W2117571600 @default.
• W2069971283 cites W2133272735 @default.
• W2069971283 cites W2142312424 @default.
• W2069971283 cites W2151042421 @default.
• W2069971283 cites W2159230430 @default.
• W2069971283 cites W2184901626 @default.
• W2069971283 cites W2249753106 @default.
• W2069971283 cites W4233782356 @default.
• W2069971283 doi "https://doi.org/10.1097/fjc.0b013e3181b04ce3" @default.
• W2069971283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19597370" @default.
• W2069971283 hasPublicationYear "2009" @default.
• W2069971283 type Work @default.
• W2069971283 sameAs 2069971283 @default.
• W2069971283 citedByCount "17" @default.
• W2069971283 countsByYear W20699712832012 @default.
• W2069971283 countsByYear W20699712832014 @default.
• W2069971283 countsByYear W20699712832015 @default.
• W2069971283 countsByYear W20699712832017 @default.
• W2069971283 countsByYear W20699712832018 @default.
• W2069971283 countsByYear W20699712832019 @default.
• W2069971283 countsByYear W20699712832020 @default.
• W2069971283 countsByYear W20699712832021 @default.
• W2069971283 countsByYear W20699712832023 @default.
• W2069971283 crossrefType "journal-article" @default.
• W2069971283 hasAuthorship W2069971283A5040996296 @default.
• W2069971283 hasAuthorship W2069971283A5067820688 @default.
• W2069971283 hasConcept C126322002 @default.
• W2069971283 hasConcept C13591479 @default.
• W2069971283 hasConcept C137183658 @default.
• W2069971283 hasConcept C181199279 @default.
• W2069971283 hasConcept C185592680 @default.
• W2069971283 hasConcept C190283241 @default.
• W2069971283 hasConcept C2777022698 @default.
• W2069971283 hasConcept C2778492669 @default.
• W2069971283 hasConcept C2778674702 @default.
• W2069971283 hasConcept C2779676291 @default.
• W2069971283 hasConcept C31573885 @default.
• W2069971283 hasConcept C35341161 @default.
• W2069971283 hasConcept C513476851 @default.
• W2069971283 hasConcept C519063684 @default.
• W2069971283 hasConcept C541997718 @default.
• W2069971283 hasConcept C55493867 @default.
• W2069971283 hasConcept C71924100 @default.
• W2069971283 hasConcept C98274493 @default.
• W2069971283 hasConcept C98539663 @default.
• W2069971283 hasConceptScore W2069971283C126322002 @default.
• W2069971283 hasConceptScore W2069971283C13591479 @default.
• W2069971283 hasConceptScore W2069971283C137183658 @default.
• W2069971283 hasConceptScore W2069971283C181199279 @default.
• W2069971283 hasConceptScore W2069971283C185592680 @default.
• W2069971283 hasConceptScore W2069971283C190283241 @default.
• W2069971283 hasConceptScore W2069971283C2777022698 @default.
• W2069971283 hasConceptScore W2069971283C2778492669 @default.
• W2069971283 hasConceptScore W2069971283C2778674702 @default.
• W2069971283 hasConceptScore W2069971283C2779676291 @default.
• W2069971283 hasConceptScore W2069971283C31573885 @default.
• W2069971283 hasConceptScore W2069971283C35341161 @default.
• W2069971283 hasConceptScore W2069971283C513476851 @default.
• W2069971283 hasConceptScore W2069971283C519063684 @default.
• W2069971283 hasConceptScore W2069971283C541997718 @default.
• W2069971283 hasConceptScore W2069971283C55493867 @default.
• W2069971283 hasConceptScore W2069971283C71924100 @default.
• W2069971283 hasConceptScore W2069971283C98274493 @default.

• next