FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069987518> ?p ?o ?g. }

• W2069987518 endingPage "571" @default.
• W2069987518 startingPage "564" @default.
• W2069987518 abstract "Age-related macular degeneration (AMD) is a disease leading to severe visual loss and legal blindness in the elderly population. The pathophysiology of AMD is complex and may include genetic predispositions, accumulation of lipofuscin and drusen, local inflammation and neovascularization. Recently four independent research groups have identified a commonly inherited variant (Y402H) of the complement factor H gene in the genome from different groups of AMD patients. The Y402H variant of CFH significantly increases the risk of AMD and links the genetics of the disease with inflammation. During inflammation there is activation of inducible nitric oxide synthase and release of nitric oxide, which in principal could lead to non-enzymatic nitration within extracellular deposits and/or intrinsic extracellular matrix protein components of human Bruch's membrane. We have identified two biomarkers for non-enzymatic nitration in aged human Bruch's membrane, indicative of inflammation, that include 3-nitrotyrosine identified in Bruch's membrane preparations and nitrated A2E from the lipid soluble extract of the Bruch's membrane preparation. Approximately 30–40 times more A2E is observed in samples of the organic soluble extract of lipofuscin compared to the extract of Bruch's membrane. It is of interest to note that although A2E is a major constituent of RPE lipofuscin, nitrated A2E could not be detected in RPE extracts. We show here that nitro-A2E is a specific biomarker of nitrosative stress in Bruch's membrane and its concentration correlates directly with tissue age." @default.
• W2069987518 created "2016-06-24" @default.
• W2069987518 creator A5026094699 @default.
• W2069987518 creator A5034104351 @default.
• W2069987518 creator A5055575460 @default.
• W2069987518 creator A5056891655 @default.
• W2069987518 creator A5063216510 @default.
• W2069987518 date "2010-05-01" @default.
• W2069987518 modified "2023-09-30" @default.
• W2069987518 title "Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane" @default.
• W2069987518 cites W1273442837 @default.
• W2069987518 cites W1491374817 @default.
• W2069987518 cites W1710437513 @default.
• W2069987518 cites W180812339 @default.
• W2069987518 cites W1882214116 @default.
• W2069987518 cites W1883306593 @default.
• W2069987518 cites W1964738612 @default.
• W2069987518 cites W1965404473 @default.
• W2069987518 cites W1970687916 @default.
• W2069987518 cites W1974615320 @default.
• W2069987518 cites W1975363458 @default.
• W2069987518 cites W1975982125 @default.
• W2069987518 cites W1976052371 @default.
• W2069987518 cites W1980685924 @default.
• W2069987518 cites W1980741996 @default.
• W2069987518 cites W1982425456 @default.
• W2069987518 cites W1986554932 @default.
• W2069987518 cites W1992058001 @default.
• W2069987518 cites W1993397750 @default.
• W2069987518 cites W1994596747 @default.
• W2069987518 cites W2000399151 @default.
• W2069987518 cites W2008189019 @default.
• W2069987518 cites W2010783235 @default.
• W2069987518 cites W2012936255 @default.
• W2069987518 cites W2014102925 @default.
• W2069987518 cites W2019665730 @default.
• W2069987518 cites W2024705346 @default.
• W2069987518 cites W2025295834 @default.
• W2069987518 cites W2033446292 @default.
• W2069987518 cites W2038140902 @default.
• W2069987518 cites W2041267856 @default.
• W2069987518 cites W2050127421 @default.
• W2069987518 cites W2051809818 @default.
• W2069987518 cites W2056617843 @default.
• W2069987518 cites W2062889513 @default.
• W2069987518 cites W2064170412 @default.
• W2069987518 cites W2067377927 @default.
• W2069987518 cites W2080061500 @default.
• W2069987518 cites W2088551743 @default.
• W2069987518 cites W2089653763 @default.
• W2069987518 cites W2090535353 @default.
• W2069987518 cites W2093910316 @default.
• W2069987518 cites W2095093319 @default.
• W2069987518 cites W2113784410 @default.
• W2069987518 cites W2116134228 @default.
• W2069987518 cites W2117386992 @default.
• W2069987518 cites W2125236492 @default.
• W2069987518 cites W2128022125 @default.
• W2069987518 cites W2132541143 @default.
• W2069987518 cites W2136501493 @default.
• W2069987518 cites W2148936029 @default.
• W2069987518 cites W2150882549 @default.
• W2069987518 cites W2151652430 @default.
• W2069987518 cites W2152699331 @default.
• W2069987518 cites W2153318203 @default.
• W2069987518 cites W2217229781 @default.
• W2069987518 cites W3145351529 @default.
• W2069987518 doi "https://doi.org/10.1016/j.exer.2010.01.014" @default.
• W2069987518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20153746" @default.
• W2069987518 hasPublicationYear "2010" @default.
• W2069987518 type Work @default.
• W2069987518 sameAs 2069987518 @default.
• W2069987518 citedByCount "54" @default.
• W2069987518 countsByYear W20699875182012 @default.
• W2069987518 countsByYear W20699875182013 @default.
• W2069987518 countsByYear W20699875182014 @default.
• W2069987518 countsByYear W20699875182015 @default.
• W2069987518 countsByYear W20699875182016 @default.
• W2069987518 countsByYear W20699875182017 @default.
• W2069987518 countsByYear W20699875182018 @default.
• W2069987518 countsByYear W20699875182019 @default.
• W2069987518 countsByYear W20699875182020 @default.
• W2069987518 countsByYear W20699875182021 @default.
• W2069987518 countsByYear W20699875182022 @default.
• W2069987518 countsByYear W20699875182023 @default.
• W2069987518 crossrefType "journal-article" @default.
• W2069987518 hasAuthorship W2069987518A5026094699 @default.
• W2069987518 hasAuthorship W2069987518A5034104351 @default.
• W2069987518 hasAuthorship W2069987518A5055575460 @default.
• W2069987518 hasAuthorship W2069987518A5056891655 @default.
• W2069987518 hasAuthorship W2069987518A5063216510 @default.
• W2069987518 hasConcept C118487528 @default.
• W2069987518 hasConcept C178790620 @default.
• W2069987518 hasConcept C181199279 @default.
• W2069987518 hasConcept C185592680 @default.
• W2069987518 hasConcept C186198217 @default.
• W2069987518 hasConcept C203014093 @default.
• W2069987518 hasConcept C2776151105 @default.

• next