Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069995708> ?p ?o ?g. }
- W2069995708 endingPage "1753" @default.
- W2069995708 startingPage "1744" @default.
- W2069995708 abstract "Differentiating eosinophilic esophagitis from gastroesophageal reflux disease is important given their pathogenetic differences and responses to therapy. Eotaxins are a family of chemokines important for activation and recruitment of eosinophils mediated by their receptor, chemokine receptor-3 (CCR-3). Interleukin 5 (IL-5) is a key cytokine involved in many steps of eosinophil production and recruitment. The aim of this study was to compare the messenger RNA expression of the eotaxins, CCR-3, and IL-5 between well-characterized groups of patients with eosinophilic esophagitis, patients with gastroesophageal reflux disease, and healthy individuals. This was a retrospective study using esophageal biopsies from 33 patients with eosinophilic esophagitis, 20 patients with gastroesophageal reflux disease, and 17 healthy controls. Parameters studied included demographic features, presenting symptoms, endoscopic findings, histopathologic features, and messenger RNA levels of eotaxins 1, 2, and 3, CCR-3, and IL-5 by quantitative real-time polymerase chain reaction using formalin-fixed, paraffin-embedded tissue. Patients with eosinophilic esophagitis were predominantly males (M/F = 3:1), with a mean age of 15.9 years and a mean eosinophil count of 55 per ×400 high-power field. Patients with gastroesophageal reflux disease had a mean age of 31.5 years and a mean eosinophil count of 5.8 per high-power field. Total intraepithelial eosinophil and lymphocyte counts, the presence of superficial eosinophil clusters, microabscesses, and basal cell hyperplasia were all significantly associated with eosinophilic esophagitis as opposed to gastroesophageal reflux disease (P < .0001). The mean expression levels of eotaxin-3 were markedly elevated in patients with eosinophilic esophagitis as compared with the gastroesophageal reflux disease and healthy control groups (731 ± 276, 31 ± 12, and 1.5 ± 0.4 pg/ng β-actin, respectively; P < .001). Mean expression levels of eotaxins 1 and 2, IL-5, and CCR-3 were also significantly increased in the patients with eosinophilic esophagitis, albeit at lower levels than eotaxin-3. In conclusion, our results highlight the important contribution of eotaxin-3 in the pathogenesis of eosinophilic esophagitis. Determination of eotaxin-3 levels by real-time polymerase chain reaction on paraffinized, formalin-fixed tissue may be a useful test in the differentiation of eosinophilic esophagitis from gastroesophageal reflux disease." @default.
- W2069995708 created "2016-06-24" @default.
- W2069995708 creator A5020115955 @default.
- W2069995708 creator A5021046502 @default.
- W2069995708 creator A5027960814 @default.
- W2069995708 creator A5030502605 @default.
- W2069995708 creator A5036318503 @default.
- W2069995708 creator A5038969005 @default.
- W2069995708 creator A5039081630 @default.
- W2069995708 creator A5053924668 @default.
- W2069995708 creator A5077088911 @default.
- W2069995708 creator A5085754608 @default.
- W2069995708 date "2007-12-01" @default.
- W2069995708 modified "2023-10-17" @default.
- W2069995708 title "Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease" @default.
- W2069995708 cites W1515144800 @default.
- W2069995708 cites W1529615153 @default.
- W2069995708 cites W1967712610 @default.
- W2069995708 cites W1974997545 @default.
- W2069995708 cites W1990867071 @default.
- W2069995708 cites W1992987846 @default.
- W2069995708 cites W2004216239 @default.
- W2069995708 cites W2012416510 @default.
- W2069995708 cites W2023152671 @default.
- W2069995708 cites W2023520187 @default.
- W2069995708 cites W2031035248 @default.
- W2069995708 cites W2032298653 @default.
- W2069995708 cites W2033043906 @default.
- W2069995708 cites W2048589504 @default.
- W2069995708 cites W2050056753 @default.
- W2069995708 cites W2051107234 @default.
- W2069995708 cites W2056640102 @default.
- W2069995708 cites W2069157452 @default.
- W2069995708 cites W2078900266 @default.
- W2069995708 cites W2095784197 @default.
- W2069995708 cites W2101965993 @default.
- W2069995708 cites W2112936403 @default.
- W2069995708 cites W2136248567 @default.
- W2069995708 cites W2137664573 @default.
- W2069995708 cites W2144846148 @default.
- W2069995708 cites W2339418744 @default.
- W2069995708 cites W4244356202 @default.
- W2069995708 cites W4254446533 @default.
- W2069995708 doi "https://doi.org/10.1016/j.humpath.2007.05.008" @default.
- W2069995708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17900656" @default.
- W2069995708 hasPublicationYear "2007" @default.
- W2069995708 type Work @default.
- W2069995708 sameAs 2069995708 @default.
- W2069995708 citedByCount "120" @default.
- W2069995708 countsByYear W20699957082012 @default.
- W2069995708 countsByYear W20699957082013 @default.
- W2069995708 countsByYear W20699957082014 @default.
- W2069995708 countsByYear W20699957082015 @default.
- W2069995708 countsByYear W20699957082016 @default.
- W2069995708 countsByYear W20699957082017 @default.
- W2069995708 countsByYear W20699957082018 @default.
- W2069995708 countsByYear W20699957082019 @default.
- W2069995708 countsByYear W20699957082020 @default.
- W2069995708 countsByYear W20699957082021 @default.
- W2069995708 countsByYear W20699957082022 @default.
- W2069995708 countsByYear W20699957082023 @default.
- W2069995708 crossrefType "journal-article" @default.
- W2069995708 hasAuthorship W2069995708A5020115955 @default.
- W2069995708 hasAuthorship W2069995708A5021046502 @default.
- W2069995708 hasAuthorship W2069995708A5027960814 @default.
- W2069995708 hasAuthorship W2069995708A5030502605 @default.
- W2069995708 hasAuthorship W2069995708A5036318503 @default.
- W2069995708 hasAuthorship W2069995708A5038969005 @default.
- W2069995708 hasAuthorship W2069995708A5039081630 @default.
- W2069995708 hasAuthorship W2069995708A5053924668 @default.
- W2069995708 hasAuthorship W2069995708A5077088911 @default.
- W2069995708 hasAuthorship W2069995708A5085754608 @default.
- W2069995708 hasConcept C126322002 @default.
- W2069995708 hasConcept C142724271 @default.
- W2069995708 hasConcept C203014093 @default.
- W2069995708 hasConcept C204232928 @default.
- W2069995708 hasConcept C2776042228 @default.
- W2069995708 hasConcept C2777014526 @default.
- W2069995708 hasConcept C2777037409 @default.
- W2069995708 hasConcept C2777129736 @default.
- W2069995708 hasConcept C2777683962 @default.
- W2069995708 hasConcept C2777716647 @default.
- W2069995708 hasConcept C2777819096 @default.
- W2069995708 hasConcept C2779134260 @default.
- W2069995708 hasConcept C2779920096 @default.
- W2069995708 hasConcept C2779929431 @default.
- W2069995708 hasConcept C2781065132 @default.
- W2069995708 hasConcept C2909576783 @default.
- W2069995708 hasConcept C43270747 @default.
- W2069995708 hasConcept C71924100 @default.
- W2069995708 hasConcept C90924648 @default.
- W2069995708 hasConceptScore W2069995708C126322002 @default.
- W2069995708 hasConceptScore W2069995708C142724271 @default.
- W2069995708 hasConceptScore W2069995708C203014093 @default.
- W2069995708 hasConceptScore W2069995708C204232928 @default.
- W2069995708 hasConceptScore W2069995708C2776042228 @default.
- W2069995708 hasConceptScore W2069995708C2777014526 @default.
- W2069995708 hasConceptScore W2069995708C2777037409 @default.