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- W2069997185 abstract "• SAMD9 is down-regulated in human non-small cell lung cancer (NSCLC). • Knockdown of SAMD9 expression is increased the invasion, migration and proliferation in H1299 cells in vitro . • Overexpression of SAMD9 suppressed proliferation and invasion in A549 cells in vitro . • Depletion of SAMD9 increases tumor formation in vivo . The Sterile Alpha Motif Domain-containing 9 (SAMD9) gene has been recently emphasized during the discovery that it is expressed at a lower level in aggressive fibromatosis and some cases of breast and colon cancer, however, the underlying mechanisms are poorly understood. Here, we found that SAMD9 is down-regulated in human non-small cell lung cancer (NSCLC). Furthermore, knockdown of SAMD9 expression is increased the invasion, migration and proliferation in H1299 cells in vitro and overexpression of SAMD9 suppressed proliferation and invasion in A549 cells. Finally, depletion of SAMD9 increases tumor formation in vivo . Our results may provide a strategy for blocking NSCLC tumorigenesis and progression." @default.
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- W2069997185 date "2014-11-01" @default.
- W2069997185 modified "2023-09-22" @default.
- W2069997185 title "Overexpression of SAMD9 suppresses tumorigenesis and progression during non small cell lung cancer" @default.
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- W2069997185 doi "https://doi.org/10.1016/j.bbrc.2014.10.054" @default.
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